L. Zheng

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

This study shows that gut microbiota influence dopamine levels, which in turn affect social interaction and color preference in zebrafish larvae.

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

This study identifies ALOX5 upregulation during breath-holding in dolphins as a potential molecular mechanism for ischemic tolerance during diving.

The paper reports the crystal structure of bromide-bound GtACR1, showing structural changes that relax constrictions in the anion tunnel, indicating a transition to a pre-activated state.

This study identifies the ERK2-p53 complex as a therapeutic target in KRAS-mutant stomach/colorectal cancers, showing that disrupting it with MEK1/2 and ERK2 inhibitors induces apoptosis.

The paper analyzes synonymous sites in SARS-CoV-2 genes to assess translational efficiency trends and their implications for viral adaptation and epidemic growth.

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

This study investigates how Duox and TLR3 genes in Hermetia illucens larvae suppress zoonotic pathogens by modulating intestinal bacterial community homeostasis through immune signaling pathways.

This study restores vision in blind mice by reprogramming Muller glia to retinal neurons, demonstrating a potential treatment for end-stage retinal degeneration.

This study shows zebrafish shoals exhibit color preferences that are lost in individuals, suggesting social interaction influences innate color preference, possibly via the dopaminergic system.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper introduces a method to create pH-responsive aptamer switches by inserting orthogonal motifs, enabling tunable affinity changes across different pH conditions.

This paper introduces a method to measure aptamer folding energy using a molecular clamp and validates it with experimental results for two aptamers.

This study validates a PET/MRI insert for multimodal imaging of vascular inflammation in mice, using iron oxide nanoparticles targeting VCAM-1 to identify inflamed regions and assess plaque stability.

The paper introduces MHCnuggets, a deep learning method for predicting MHC class I and II neoantigen binding, showing improved performance and scalability across 26 cancer types.

The paper compares the proteomes of vegetative cells and spores of Clostridioides difficile to identify potential biomarkers for infection.

The paper develops a method to generate scaled musculoskeletal neck models using anthropometric data and optimization, showing accuracy in geometry and strength.

This study shows that miR-383 suppresses Bcl-2 translation, promoting apoptosis in gastric carcinoma cells during chemotherapy.

This paper presents the X-ray structure of GtACR1, revealing a novel mechanism for anion conductance involving the Schiff base and tunnel architecture.

The paper investigates how WRN exonuclease deficiency affects replication fork recovery from camptothecin, showing RAD51 and MUS81 mitotic function are essential to prevent genome instability.

The paper presents the structure of human TRPC6 ion channel in complex with inhibitor BTDM, revealing its architecture and inhibition mechanism.

This study investigates how morphology and mechanical properties of snake scales influence tribological behaviors, proposing a 'double-crossed' hypothesis to explain their coupling effect.