M. Huang

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study investigates how HIV-1 Nef's flexible regions interact with its core domain to influence SH3 domain selectivity and identifies few human proteins with similar binding properties.

This study identifies aglycone polyether ionophores as broad-spectrum antivirals effective against multiple enveloped viruses, including SARS-CoV-2, and demonstrates their efficacy in curing JEV-infected mice.

This study uses deep sequencing to characterize full-length TprK diversity in T. pallidum strains from human infections, revealing near-complete sequence divergence and estimating high antigenic variation potential.

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

The paper proposes a method to develop calibration guidelines for system models by analyzing multi-model simulations, applying it to crop model phenology calibration and providing recommendations on objective functions, parameters, and software.

This study examines how SARS-CoV-2 induces antiviral host responses, showing differences by viral load, age, and sex in gene expression profiles from infected individuals.

This paper shows SARS-CoV-2 ORF6 interacts with Rae1 and Nup98 to disrupt nucleocytoplasmic transport, reducing reporter expression and causing nuclear mRNA accumulation, more strongly than SARS-CoV ORF6.

This study evaluates wheat phenology prediction models in Australia, finding that multi-model averaging performs nearly as well as the best single model, with an average error of 9 days.

This study shows that gut microbiota impair insulin clearance during obesity, with specific bacterial taxa linked to this effect, suggesting potential therapeutic targets.

This study clones, expresses, and evaluates the in vitro anticancer activity of Lp16-PSP, a protein from Lentinula edodes, showing selective cytotoxicity against HL-60 cells.

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

This study quantifies the Zn uptake and distribution requirements needed to achieve high grain Zn concentration in high-yield wheat on low-Zn calcareous soils.

This study evaluates how well 27 crop modeling groups predict wheat phenology in Northern France using calibration data from the same target population, finding mean absolute errors comparable to measurement error.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.

The paper detects highly fragmented CMV nucleic acid in maternal cfDNA and shows its distinct fragment length distribution compared to human cfDNA, which may explain discrepancies in qPCR measurements.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

The paper identifies a plant MLKL protein family structurally similar to vertebrate MLKL, which provides immunity against pathogens without inducing cell death.

This paper examines the feasibility of detecting atrial and ventricular arrhythmias using complexity metrics of heartbeat intervals, achieving 100% recall and precision with a 600-heartbeat-length signal.

This paper shows that dopamine receptor 2 activation in glioblastoma cells increases their growth, stemness, and metabolic activity, suggesting dopamine signaling as a therapeutic target.

This study shows HA-stalk-reactive antibodies inhibit neuraminidase activity via steric hindrance, blocking viral egress and enhancing protection against influenza.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.