Q. Wang

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

The paper assesses the suitability of Salmonella gene targets for PCR-based diagnostic testing using genomic data from 3165 isolates, finding varying levels of nucleotide dissimilarity across targets.

This paper identifies chromogranin B (CHGB) as the anion channel essential for secretory granule maturation and acidification in regulated secretion.

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

This study shows that deoxynivalenol (DON) promotes PEDV infection and worsens gut barrier injury by inducing autophagy and impairing innate immunity.

This paper develops a method to produce human amniotic epithelial cells-only membrane with higher purity and clinical potential for wound healing.

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

This study shows SPOP promotes ubiquitination and degradation of MyD88, suppressing innate immune responses and reducing susceptibility to Salmonella typhimurium infection.

This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

This study develops a serum-free method to generate human mesenchymal stem cell spheroids using knockout serum replacement, showing similar transcriptomes to FBS-based spheroids and retained MSC markers.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.

This study shows CaMKII oxidation by ROS evolved in vertebrates to enhance performance but increased disease risk.

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

This study uses single-cell profiling to identify immunosuppressive cells in CDK4/6 inhibitor-resistant HER2+ breast cancer and shows that combinatorial immunotherapy can overcome resistance.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This study introduces a dual scintillator configuration for radioluminescence microscopy, doubling sensitivity and halving image acquisition time for short-lived radiotracers.

This paper demonstrates that GXMR-CAR+ T cells can effectively target and reduce Cryptococcus neoformans burden in a murine model.

This study uses a computational model to explore optimal dosing and timing of IL-12 and Oxaliplatin combination therapy for liver-metastatic colorectal cancer in mice.

This study compares biodegradable mulch film with polyethylene plastic film in cotton and maize, finding higher yield and water use efficiency with biodegradable film without residual pollution.

The paper investigates positive selection for mRNA secondary structure at synonymous sites in domesticated yeast, finding that GC content and structure influence translational efficiency and adaptation.

This study compares the efficacy of new bio-pesticides and conventional chemical pesticides against Tetranychus cinnabarinus, finding abamectin to be the most effective.