R. Liu

This paper introduces a GPU-accelerated all-atom continuous constant pH MD method with PME electrostatics in Amber22, validated on six proteins with improved pKa accuracy and biological relevance.

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

This study identifies a circadian clock control of MRTF-SRF signaling that suppresses beige adipocyte thermogenic recruitment and maintains metabolic homeostasis.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

The paper identifies Pericentrin-Like-Protein (PLP) as a Kinesin-1 activator that drives centriole motility during interphase.

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

This study identifies miR-132 as a critical regulator of lymphangiogenesis, showing its role in lymphatic remodelling through in vitro and in vivo experiments.

The paper introduces colorimetric and fluorescent TRAP assays for visualizing and quantifying osteoclast activity in zebrafish and medaka, showing fluorescent TRAP staining is effective and compatible with other techniques.

This study isolates a marine fungus capable of efficiently degrading polyethylene, identifying degradation products and enzymes involved in the process.

This study shows that neural crest-derived BMP7 is important for retina development and function, as its deletion leads to structural and functional abnormalities in the retina.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

This study uses CpHMD simulations to analyze cysteine reactivity in kinase N-cap positions, finding that some are reactive while others are not, depending on nearby residues.

This paper introduces a cyborg brain organoid platform for long-term 3D electrophysiological recording, enabling continuous monitoring of single-cell action potentials during brain organoid development.

CODEC improves mutation detection by combining NGS throughput with single-molecule resolution, achieving similar accuracy with fewer reads.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

The paper describes a method to measure mitochondrial electron transfer complexes in previously frozen cardiac tissue from offspring of exercised sows to assess exercise-induced mitochondrial bioenergetics changes.

The paper introduces a model (IsoDyn) to quantify isotopic incorporation rate and trophic discrimination, showing it provides better fits than simpler models with minimal calibration.

This paper presents a deformable microfluidic device using microbeads to separate plasma and retrieve blood cells, supported by imaging and computational modeling.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

This study identifies a sulfate-reducing bacterium that forms zero-valent sulfur through sulfide oxidation, highlighting a new pathway in the sulfur cycle.

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

The paper examines chemical defense and tonic immobility in early life stages of Murgantia histrionica, finding eggs are more chemically defended than early nymphs, while tonic immobility is favored by hatchlings.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.