R. Liu

The paper isolates and characterizes a novel Chloroflexi strain, showing its role in sulfur cycling through assimilatory sulfate reduction.

This study shows that recombinant MVA vaccines expressing modified S proteins inhibit SARS-CoV-2 replication and prevent lethal disease in transgenic mice.

This study characterizes the first cultured free-living Candidatus Izimaplasma strain, revealing its unique DNA-degrading capabilities and ecological role in deep-sea methane seeps.

The paper shows Bacteroidetes are key to deep-sea carbon and nutrient cycling by degrading diverse glycans through metagenomics, isolation, and transcriptomic/metabolomic analyses.

This study identifies aglycone polyether ionophores as broad-spectrum antivirals effective against multiple enveloped viruses, including SARS-CoV-2, and demonstrates their efficacy in curing JEV-infected mice.

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study reports cryo-EM structures of the human DUOX1-DUOXA1 complex in different calcium states, revealing structural features and calcium regulation of its catalytic activity.

The paper shows SMIFH2 inhibits myosin ATPase activity and actin filament translocation, affecting myosin 2A, myosin 10, and other non-muscle myosins, suggesting caution in using SMIFH2 to infer formin function.

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

This study introduces a visible light OCTA system for human retinal imaging, achieving high-speed acquisition and microvascular oximetry with sub-100 μm vessel resolution.

This paper introduces a coupled simulation toolkit combining Geant4 and CompuCell3D to model radiation effects on tissue, enabling simulation of tumor response to radiation therapy.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper reports that Heimdallarchaeota, a group of archaea, possess proteins associated with photosynthesis and may perform oxygenic photosynthesis, suggesting a photomixotrophic lifestyle.

This study analyzes DPANN archaea from deep-sea hydrothermal vents to understand their metabolism and ecological roles, revealing their genomic features and potential contributions to biogeochemical cycles.

This study identifies Schisandrin B as a potential treatment for male infertility by improving sperm count, mobility, and reproductive ability in a mouse model.

This study shows that competition between kinesin-1 and myosin-V, influenced by cortical microtubule density, determines posterior localization of osk mRNA in Drosophila oocytes.

The paper identifies ACPT gene inactivation in toothless and enamel-less mammals and estimates its inactivation times across different lineages.

This study shows SPOP promotes ubiquitination and degradation of MyD88, suppressing innate immune responses and reducing susceptibility to Salmonella typhimurium infection.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

The paper tests how changes in geomagnetic field intensity affect migration-related traits in the brown planthopper, finding responses in morphology, behavior, and physiology.

This study reports cryo-EM structures of human sGC 1β1 heterodimer in different states, revealing the structural mechanism of NO-induced activation.

This study identifies ERF109 as a regulator of auxin transport in Arabidopsis roots by directly controlling PIN2, PIN4, and PID, which are key components of auxin transport.