S. Gupta

This study investigates the structural domains of FtsY in Sulfolobus acidocaldarius that facilitate SRP54 binding and membrane association during protein translocation.

This study uses scRNA-seq to show that circulating human neutrophils are transcriptionally heterogeneous, forming four distinct clusters with distinct transcriptional states.

The paper investigates NTCP and HBV replication markers in placental cells, finding NTCP expression and viral markers suggesting placental susceptibility to HBV and potential replication.

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

This study uses PET and fluorescent microscopy to track HIV distribution in neonatal rhesus macaques after oral challenge, showing virions localize to the rectal mucosa by four hours and the intestine contains the most infected cells at 96 hours.

This study shows CALR mutations in iPS cells from MPN patients accelerate megakaryocyte maturation and identify hypoxia signaling as a therapeutic target.

This study investigates how the geometry of 3D DNA nanostructures affects their cellular and in vivo uptake, finding that tetrahedral shapes are more efficiently internalized.

Loss of Kat2a enhances transcriptional variability of ribosome biosynthetic programs and transiently accelerates pre-leukemia.

This study develops a mouse model showing that complete loss of BAP1 function is required for KRAS-driven intrahepatic cholangiocarcinoma.

This study develops and tests mechano-active microcapsules containing osteogenic factors in a large animal model to preserve bone structure after osteochondral injury.

The paper investigates how temporal processing by midbrain auditory neurons contributes to species recognition in two cryptic treefrog species.

This study shows that Pten downregulation is essential for zebrafish retina regeneration by promoting Muller glia-derived progenitor cell proliferation through Akt and Mmp9/Notch pathways.

The paper uses cell-derived nanovesicles and single-molecule imaging to study ligand binding dynamics at a cyclic nucleotide-gated ion channel, revealing previously undetected conformational changes and non-cooperative binding behavior.

The paper describes three new nematode species found in the syconia of Ficus racemosa in southern India and confirms their phylogenetic relationships using rRNA gene analysis.

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.

The paper shows that RhoA signaling at adherens junctions stabilizes E-cadherin during epithelial migration by increasing junctional contractility and mechanical tension.

This study identifies loci and evolutionary forces underlying herbicide resistance in weeds, finding interchromosomal linkage disequilibrium and fitness cost loci associated with resistance.

This paper develops a model showing vimentin-null cells move faster and are more persistent in confined spaces due to reduced nuclear positioning and microtubule orientation.

The paper investigates H2A isoform expression across normal tissues and tumors, finding tissue-specific patterns and cancer-specific overexpression of HIST2H2AC.

This study identifies Myoferlin as a lysosomal membrane integrity factor in pancreatic cancer, showing its role in lysosome health and tumor growth.

This study identifies BPLF1 as a regulator of TOP2 activity during EBV replication by modulating ubiquitination, SUMOylation, and DNA-damage response.

This study compares three marrow stimulation techniques in minipigs, finding that needle-puncture best preserves subchondral bone compared to drilling and microfracture.

This study investigates how SARS-CoV-2 affects central carbon metabolism in host cells and links metabolic changes to disease severity.

This study identifies a regulatory module involving HB40, JUB1, GA2ox, and DELLA proteins that controls gibberellin homeostasis in Arabidopsis by modulating GA biosynthesis, deactivation, and signaling.

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

This study identifies delayed and dysregulated type-I interferon signaling in SARS-CoV-2 infected Huh7 cells and shows that IFN-I pretreatment reduces susceptibility.

The paper shows sex-specific differences in ABCs expansion, ISG signature upregulation, and differentiation in TLR7-driven immunopathogenesis, with Tlr7 duplication in males exacerbating disease severity.

The paper identifies extracellular vimentin as a potential target for preventing SARS-CoV-2 infection by showing it facilitates viral entry through interaction with the spike protein and ACE2.

This study identifies somatic CTCF mutations in cancer and shows how their structure-function relationships affect cellular phenotypes and tumour suppressor function.

This study shows that a recombinant fragment of human SP-D inhibits SARS-CoV-2 spike protein binding to ACE-2 and reduces viral replication in clinical samples.