S. Gupta

This study evaluates the antimalarial effect of Prasugrel, an FDA-approved purinergic receptor antagonist, on Plasmodium falciparum by targeting PfSR12, a putative purinergic receptor.

This study uses multi-omics approaches to analyze host-viral interactions in CCHFV infection, identifying metabolic reprogramming and interferon-mediated antiviral mechanisms as potential therapeutic targets.

This study uses molecular dynamics simulations to analyze how mutations at conserved residues E371 and S359 affect the structural dynamics of ZPI, revealing their role in RCL flexibility and protease inhibition.

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

The paper shows that PERK-mediated repression of miR-17-92 cluster promotes ER stress-induced apoptosis through NRF2.

The paper examines alpha globin variation in long-tailed macaques and finds it correlates with malaria selection, suggesting similar adaptive processes to humans.

This study investigates how Trichoderma harzianum T-22 affects biochemical changes in barley under salt stress using metabolomics.

This study shows vimentin enhances cell spreading on viscoelastic substrates but not elastic ones, suggesting it modulates cell mechanosensing.

This study uses molecular dynamics and experimental methods to show that phosphorylation of CheY increases its affinity for FliMN by altering conformational dynamics and sidechain burial.

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

The paper identifies primary carbohydrate metabolism genes involved in heat stress memory at the shoot apical meristem of Arabidopsis thaliana, showing their role in survival after lethal heat stress.

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

The paper shows that DNA methylation reduces H3.3 levels in HCC, affecting transcription and cell proliferation, and suggests DNMT and HDAC inhibitors as potential therapies.

The paper investigates the distinct roles of ATAC and SAGA KAT2A complexes in normal and malignant hematopoiesis, showing ATAC's essential role in stem/progenitor cell maintenance and SAGA's role in cell identity.

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.

This study identifies p38/MAPK pathway activation as a convergent mechanism driving survival, immune evasion, and metastasis in hormone-resistant prostate cancer.

This study compares gene expression under heat stress in two Indian cattle breeds, finding Tharparkar better adapts through upregulated stress response and antioxidant genes.

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.

This study identifies 14-3-3I as a scaffold protein in Plasmodium falciparum and reveals its interaction with CDPK1, a key kinase, through phosphorylation-dependent binding, suggesting a potential target for antimalarial drug development.

The paper identifies a novel CDPK1 inhibitor from a molecular library that inhibits P. falciparum intra-erythrocytic growth in vitro.

This study identifies dynamin-like proteins IniA and IniC as essential for extracellular vesicle biogenesis in Mycobacterium tuberculosis under iron limitation and VirR restriction.

A 6-week core training program improved swimming performance in elite swimmers by enhancing start, turn, and overall freestyle speed.

This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.

The paper identifies PDGFRA+ bone marrow-derived mesenchymal stem cells as Kaposi’s sarcoma progenitors and shows pro-angiogenic conditions enable KSHV oncogenesis through epigenetic de-repression.

The paper identifies LRX proteins as RALF1 receptors interacting with FERONIA to regulate cell growth in Arabidopsis, showing functional conservation across different cell types.

This study identifies and evaluates gestural communication in wild bonnet macaques in Bandipur National Park, providing a foundation for comparative primate studies on language evolution.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This paper develops a CRISPR-Cas9-based pipeline to generate pancreatic cancer mouse models with complex genotypes using AAV-delivered sgRNAs in adult mice.

The paper analyzes leaf shape variation in sweetpotato using morphometric and transcriptomic approaches, finding that genetics largely drive shape variation but environment plays a significant role with quantitative measures.