W. Wang

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

This study identifies sRNA candidates in Alcanivorax dieselolei B-5 under alkane and non-alkane conditions, revealing their roles in alkane metabolism and adaptation.

The paper identifies RNA phase separation as a novel pathway for extracellular miRNA uptake and shows that these miRNAs are delivered to mitochondria via PNPT1.

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

This study improves the phylogenetic understanding of Lepidoptera by increasing taxon sampling and analyzing the impact of sampling and long-branch attraction on tree topology.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

The paper investigates RNA inheritance after mitosis, finding that half of nuclear RNAs are inherited transcription-independently, with snRNAs like U2 being retained while lncRNAs like NEAT1 and MALAT1 are not.

The paper uses particle fusion of single molecule localization microscopy data to determine the dimer structure of Nup96 in the Nuclear Pore Complex, showing 32 copies per pore.

The paper determines the crystal structure of monkeypox H1 phosphatase, revealing its dimeric form and active site, which informs antiviral drug development.

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

This study reveals how GTP cycling gates CTP synthase activation through three sequential checkpoints, linking GTP binding and dissociation to catalytic steps in CTP synthesis.

The paper develops and tests novel DMDC-derived compounds as copper-dependent antimicrobials against Streptococcus pneumoniae, showing effectiveness in vitro and in vivo.

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

The paper shows that FUS condensates during aging exhibit solid/liquid coexistence, with the transition initiated at the interface between dense and dilute phases.

This study identifies CD98 as critical for inflammatory responses to injury stimuli in IPF exacerbations and COVID pneumonitis, showing its role in IL-6 and IL-8 responses and fibrosis progression.

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

The paper compares antibody responses to different SARS-CoV-2 variants after vaccination and infection, finding that post-vaccination Omicron infection induces broader immunity than triple vaccination alone.

This study observes and attributes intermittent bioluminescence blinking in native bacteria to stochastic gating of Na+/H+ antiporters, revealing their dynamic behavior in living cells.

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

The paper identifies two substrate-binding sites in pOmpT that enable specific cleavage of human AMP RNase 7, revealing structural basis for substrate specificity and drug development clues.

This study characterizes the entry mechanisms and antibody neutralization resistance of Omicron variants BA.1, BA.1.1, BA.2, and BA.3 compared to the D614G strain.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.

This study shows Aspergillus tabacinus LZ-M can degrade acid red 73 anaerobically through a self-redox mechanism, mineralizing it to CO2 with a 90.28% decolorization rate in 5 days.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.