W. Wang

This study identifies a repression domain in Arabidopsis TPL that interacts with Mediator subunits, essential for transcription repression in yeast and plants.

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This paper presents a biosensor using G-FETs and dielectrophoresis to rapidly and selectively detect antibiotic-resistant bacteria at the single-cell level.

This study identifies a novel RecJ from Bacillus alcalophilus with endonuclease activity, distinct from previously known exonucleases, and highlights its potential as a gene editing tool.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

This study examines the effect of insulin therapy on OCT/A measurements in diabetic patients without retinopathy, finding thinner MCT and lower PVD in insulin users.

The paper uses time-lapse imaging to study EMT in human cells, revealing two distinct transition paths through a multidimensional feature space.

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This paper introduces GNEPS, a fluorescent sensor that detects intracellular GTP:GDP ratios in real-time, showing its utility in monitoring metabolic changes across cell types and organelles.

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

This study examines testosterone level changes in female giant pandas during estrus and finds that testosterone peaks 4 days after estradiol peaks and is only correlated with estradiol after the estradiol peak.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This study identifies how abnormal nitration and S-sulfhydration of the Sp1-CSE-H2S pathway contribute to the progression of hyperhomocysteinemia through a self-reinforcing cycle.

This paper develops a mechanochemical model to study how cell tension affects migration, showing it inhibits movement under persistent stimuli but can enhance migration under random noise.

This study traces the evolutionary origin of the Hippo pathway from unicellular ancestors and examines its oncogenic alterations in mammals.

This study shows that cutaneous lymphoma subclones evolve independently in different skin microenvironments, leading to ecological heterogeneity and intratumoral heterogeneity.

This study shows that Aurora-B phosphorylates SAF-A to remove RNA from chromosomes during prophase, preventing anaphase segregation errors.

The paper uses molecular dynamics simulations to study how cleavage of SAA protein affects its down-regulation and aggregation potential, proposing a mechanism involving conformational switching and environmental conditions.

This study identifies branched evolutionary patterns and intratumoral heterogeneity in mycosis fungoides, revealing complex clonal substructures and their implications for treatment resistance.

This study examines how substrate stiffness affects human umbilical vein endothelial cell behavior, finding increased CX40 and GAG content and decreased actin stress fibers and proliferation on stiff substrates.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

The paper analyzes gene expression dynamics in C. elegans to show rapid molecular evolution in genes with declining transcript abundance during early embryogenesis, challenging existing evolutionary models of development.