X. Cao

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This study identifies the molecular basis of fidaxomicin's narrow-spectrum activity against Clostridioides difficile by analyzing its interaction with RNA polymerase.

This study identifies PLEKHA5 as a microtubule adaptor that spatially regulates APC/C activity during mitosis by facilitating its localization to microtubules and interaction with CDC20.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study identifies ADAR2 downregulation in t(8;21) AML and shows its role in suppressing leukemogenesis through RNA editing.

This study shows that JAK/STAT signaling, activated by tumor-derived Upd cytokines, delays Drosophila metamorphosis by coopting its developmental role in the prothoracic gland.

This study identifies ID1 upregulation in DIPG tumor cells and shows that CBD can reduce ID1-driven invasiveness in vitro and in vivo.

This paper develops a genetic mouse model of MPNST that closely mimics human tumors in genetics, histology, and transcriptome.

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

The paper shows that Clp protease and AscarD regulate CarD levels to help mycobacteria survive starvation by reducing rRNA synthesis.

This paper shows that SARS-CoV-2 RdRp undergoes backtracking, which may aid proofreading and antiviral resistance.

This study shows that high-dose sodium butyrate causes reversible metabolic paralysis by inducing transient mitochondrial reprogramming in the brain, specifically through ANT protein activation and proton leak.

This study shows that SARS-CoV-2 Spike protein activates macrophages and induces acute lung inflammation in mice.

This paper introduces an automated framework for detecting and tracking ants in videos, achieving high accuracy and speed in both indoor and outdoor environments.

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

The paper characterizes a clinical Enterobacter hormaechei strain co-carrying blaNDM-1, blaIMP-4, and mcr-9.1, highlighting the convergence of resistance genes in an epidemic clone.

This study shows that reduced IF1 in obesity leads to mitochondrial reprogramming through ANT2 downregulation, improving insulin sensitivity despite increased body weight on a high-fat diet.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

The paper shows that applying active mechanical forces to human neural tube organoids enhances their patterning and growth through temporally restricted mechanoregulation.

This study investigates the force-dependent unwinding activity of SARS-CoV-2 nsp13 helicase using optical tweezers, revealing increased unwinding frequency, processivity, and velocity under destabilizing force.

This study identifies PLEKHA4 as a regulator of Wnt/β-catenin signaling that promotes melanoma proliferation and survival, with potential as a therapeutic target.

The paper demonstrates that the cytosolic thioredoxin reductase pathway reduces ER-localized proteins via a membrane protein, essential for ER redox homeostasis and protein folding.

This paper reprograms the endogenous CRISPR-Cas10 system in Mycobacterium tuberculosis for efficient gene editing, RNA interference, and genome-wide screening, enabling functional genomics studies and drug/vaccine development.

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

The paper identifies RNA G-quadruplex structures in Arabidopsis and rice, showing they regulate translation and plant growth.

This study investigates how protein secondary structure influences disulfide formation during folding, showing that disulfide-driven and folding-driven mechanisms depend on structural features.