X. Li

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

This study shows TDP-43 pathology activates immune cells in ALS, linking it to immune dysfunction and suggesting immune monitoring as a diagnostic tool.

This study analyzes the genomic and transcriptomic features of the Type VI secretion system (T6SS) in Klebsiella pneumoniae, showing its presence in all clinical isolates and its role in interbacterial competition.

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

This study uses metabolomics to show that palmitic acid alters N-glycosylation-related metabolites in THP-1 macrophages, linking them to TLR4 activation and inflammation.

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

The paper identifies spatial interactions between NOS2, COX2, and T-effector cells in ER- breast cancer, linking these patterns to poor patient outcomes and suggesting potential therapeutic strategies.

This paper presents a cryo-EM structure of CXCL12-bound CXCR4 in an active state, revealing key interactions that stabilize the ligand-receptor complex.

This study identifies NOS2 and COX2 as key spatial targets in ER- breast cancer that influence immune phenotypes and clinical outcomes through spatial analysis of tumor microenvironments.

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

This study uses single-cell RNA-seq to analyze the progression from actinic keratosis to cutaneous squamous cell carcinoma, identifying key driver genes and tumor microenvironment interactions.

This study shows quorum sensing in V. alginolyticus increases CPS-dependent phage infection by upregulating ugd gene expression and CPS synthesis.

This study shows vitamin D reduces diabetic myocardial injury by inhibiting the Erbb4/ferroptosis pathway in both in vivo and in vitro models.

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.

This study identifies SARS-CoV-2 NSP13 as a suppressor of Hippo-YAP signaling by interacting with TEAD and remodeling chromatin to inhibit YAP transcriptional activity.

This paper introduces FABCON, a tool for detecting lipid droplet-organelle contact sites in living cells, showing their dynamic behavior under different metabolic conditions.

This study determines the cryo-EM structures of SIR2, HerA, and their complex, revealing their structural basis for antiphage activity and functional interactions.

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

scDrugPrio uses single-cell RNA sequencing to prioritize drugs for immune-mediated inflammatory diseases, showing personalized drug response variations across patients.

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

This paper develops protein-protein hydrogels using thiolation and Ag-S bonding to enhance wound healing properties in both diabetic and UV-burn models.

The paper shows Duox in Drosophila Malpighian tubules produces ROS that trigger Upd3 release, which then stimulates gut epithelial renewal via a countercurrent flow system.

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.