X. Li

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

The paper shows that the cell division machinery in Bacillus subtilis drives asymmetric localization of DivIVA and SpoIIE, leading to cell-specific activation of σF during sporulation.

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

The paper introduces EASi-seq, a method for single-cell sequencing of microbes using a commercial platform, enabling detailed microbiome atlases and improved bioinformatic analysis.

This study shows that reducing CERS1 in skeletal muscle worsens age-related muscle dysfunction in mice and humans, linking it to inflammation and fibrosis.

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

This study shows that matrix confinement affects 3D spheroid sorting and collective migration, with sorting dependent on cell-cell adhesion and matrix resistance.

This study reveals the ion selectivity and activation mechanism of kalium channelrhodopsins through cryo-EM structures of various variants.

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

This study identifies a specific subset of tumor-associated endothelial cells in PDAC and develops a prognostic model, TaEMS, to predict patient outcomes based on immune and cellular pathway profiles.

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

This paper identifies Gal83 as a target of Fus3-MAPK and shows it regulates aflatoxin synthesis substrates through crosstalk with Snf1/AMPK in Aspergillus flavus.

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

This paper develops a method to biodecompose Spirulina platensis using Bacillus subtilis to create a medium for high cell-density cultivation of Escherichia coli, achieving higher growth rates and optical density than traditional LB broth.

CherryML provides a scalable method for maximum likelihood estimation of phylogenetic models, achieving significant speedup in parameter estimation for molecular evolution.

This study identifies GDF15 as a new hypoglycemia counterregulatory hormone, showing it increases hepatic gluconeogenesis through renal release and beta-adrenergic receptor-2 signaling.

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

This study examines the distribution and metabolomic effects of PCB 52 in female rats after intraperitoneal exposure, finding metabolites in serum and liver with minor changes in serum metabolites.

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This study examines the physiological effects and chemotherapeutic sensitivity of tetraploid C. elegans, finding longer worms, shorter lifespan, smaller brood size, and altered reproductive traits.

This paper identifies a matrix code based on extracellular core matrix proteins that categorizes glioblastoma tumors into prognostic groups and predicts responses to PD1 blockade.

This study investigates how drought affects the active bacterial communities in the rhizosphere of switchgrass and common bean, distinguishing between plant- and environment-mediated effects.

This study uses laser-assisted micropatterning to engineer cell and nuclear morphology on nanopillar platforms, showing disrupted nuclear-cell shape coupling and enhanced endocytosis on nanopillars.

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

This study identifies HDAC4-mediated deacetylation of GSDMD as a mechanism to inhibit pyroptosis by preventing GSDMD ubiquitination.

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.