Y. Tang

This paper develops a biosensor system to monitor cell-cell interactions induced by therapeutic antibodies in 3D cultures, showing faster NK cell interactions compared to T cells.

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

This paper develops a mass spectrometry method to detect microproteins in vaginal lavages and identifies cystatin A as a potential biomarker for early ovarian cancer detection.

The paper shows that parasite-induced limb movements in male frogs enhance the attractiveness of acoustic signals by incorporating visual elements, influencing female mate choice.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

This study investigates how β-ecdysterone affects fracture healing by modulating autophagy via the PI3K/AKT/mTOR pathway in osteoblasts.

This study identifies dipeptides as minimalistic yet sufficient for liquid-liquid phase separation through computational and experimental methods.

This study uses mass cytometry to analyze immunological changes in mice after radiation-induced cardiac fibrosis, finding increased macrophages and pro-fibrotic cytokines.

This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.

This study shows that loss of Rab35 or Arf5 in glioblastoma cells increases tumor growth and invasiveness by activating the epidermal growth factor receptor and upregulating SPOCD1.

This study compares 15 fish species to identify genomic signatures of alkaline adaptation in both highland and lowland fish, finding consistent patterns of accelerated evolution and positive selection in shared genes.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This study shows that KAI2a and KAI2b in Lotus japonicus have divergent ligand-binding specificities and organ-dependent redundancy in response to karrikin ligands.

This paper improves ELISPOT assay sensitivity for detecting neoantigen-specific T cells by co-stimulating with anti-CD28 and IL-2, increasing detection by up to 5-fold.

HiFi-SIM improves structured illumination microscopy image fidelity by reducing artifacts and enhancing axial resolution without requiring precise PSF calibration or parameter tuning.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

The paper identifies AMR4, a CaaX-like protease in Plasmodium parasites, which is essential for apicoplast biogenesis but does not function in the expected CaaX post-prenylation pathway.

This study models antibody-target binding dynamics in tumors using BRET imaging and finds spatial differences in cetuximab binding to EGFR.

This study introduces a quantitative metric to evaluate therapeutic antibody doses and identifies factors influencing dose selection beyond traditional pharmacokinetics and target binding affinity.

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

This paper introduces a novel class of self-assembling dsRNA therapeutics that target specific oncogenic sequences and induce apoptosis in cancer cells.

This study examines the effects of dietary Citrus reticulata 'Chachi' products on the fecal microbiome of weaned piglets using multi-omics analyses, showing changes in microbial diversity, SCFAs, and proteomic profiles.

This study investigates the effects of human umbilical cord mesenchymal stem cell transplantation on preserving and restoring fertility in aging and chemotherapy-damaged female mice.