Y. Wang

This study identifies the thermodynamic state of aerobic glycolysis (TSAG) as a system property that stabilizes glycolytic flux in cancer cells, showing it resists perturbations and requires both enzyme inhibition and TSAG disruption for effective AG inhibition.

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

This paper uses phylogenomic analysis of transcriptomic data to reclassify anaerobic gut fungi into four families and emend existing ones, providing quantitative estimates for taxonomic ranks.

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

The paper develops PiSPA, a single-cell proteomic workflow, to quantify up to 3000 protein groups in tumor cells, demonstrating its utility in studying single-cell proteome dynamics.

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

This study investigates how DIV1 infection in Marsupenaeus japonicus affects intestinal microbiota, metabolomics, and immune response, revealing secondary bacterial infection and metabolic reprogramming.

This study investigates the divergent evolution of zygomycete fungi, identifying lineage-specific genomic elements and evolutionary relationships that contribute to Mucormycosis pathogenicity.

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

The paper develops liver-derived cell lines from cavefish Astyanax mexicanus to study metabolic adaptation and provides their characterization.

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

This paper introduces a new eccDNA purification method and a full-length sequencing approach to improve eccDNA analysis and mapping.

This study investigates the effects of FABP1 and FAS overexpression on collagen III and cross-linking in Zongdihua pig tissues, identifying their roles in fat deposition.

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

The paper isolates a novel thermophilic bacterium from a deep-sea hydrothermal vent and identifies it as part of a deep-branching clade that provides insights into early bacterial evolution.

This paper shows that ascorbic acid-derived carbon dots (VCDs) improve circadian rhythm and reduce hyperactive behavior in a zebrafish ADHD model caused by per1b mutation.

This study shows benzidine promotes bladder cancer cell proliferation via the ERK5 pathway by increasing cyclin D1 and PCNA while decreasing p21.

This paper develops photoswitchable nanovesicles (azosomes) for precise optical control of molecular release in neurons, demonstrating their ability to activate dopamine receptors in cultured striatal neurons.

The paper identifies lineage-specific genes (LSGs) in Neurospora crassa that cluster with allorecognition loci and respond to environmental factors regulating the switch from asexual to sexual reproduction.

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.

The paper identifies a conserved membrane protein that negatively regulates Mce1 complexes in mycobacteria by inhibiting transporter assembly.

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

This study develops a DNA extraction protocol (LPQ) that achieves saturated cell lysis for microbiome analysis, outperforming existing methods in detecting microbial differences.

This study identifies PPP2R1A's role in migration persistence via the WAVE Shell Complex, showing its tumor suppressor function through actin regulation.

The paper identifies PPIX-binding proteins and shows that increased heme/porphyrin synthesis promotes ferroptosis distinct from canonical ferroptosis, with PRDX3 modulating this process.

This study identifies a remodeled RNA polymerase II complex that catalyzes viroid RNA-templated transcription, distinct from DNA-template Pol II complexes.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

The paper reanalyzes PANDORA-seq data to show 28s5-rtsRNA is abundant and functions with 5.8s rRNA-derived small RNA to reduce ribosomal protein mRNA levels, with key nucleotides identified through mutational scanning.