Y. Wang

This study identifies cost-effective primer pairs and develops a tool to enhance eDNA-based monitoring of freshwater biodiversity.

This study identifies serine hydroxymethyl transferase (SHMT) as a binding target of caprylic acid, showing its role in herbicidal activity and potential for developing tolerant crops.

This study identifies umbrella toxin particles produced by Streptomyces that inhibit the growth of competing bacterial species, distinct from small molecule antibiotics.

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

WYMV P2 protein acts as a VSR by interfering with CaM-CAMTA3 interaction to enhance virus systemic infection in wheat.

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

The paper maps lncRNA landscapes across ten cancer types using single-nucleus RNA sequencing and identifies cell type-specific lncRNA-mRNA pairs and regulatory networks.

The paper isolates a facultative anaerobic electrogenic strain Klebsiella sp. SQ-1 and demonstrates its high current density and power density in microbial fuel cells.

This study shows that co-administering immunogenic MVA and G-CSF activates neutrophils to kill MPNST tumors in a murine model.

This paper develops an MRI-compatible transrectal ultrasound and photoacoustic imaging system for prostate cancer diagnosis, demonstrating its feasibility in phantom and ex-vivo settings.

This study evaluates folate-conjugated miR-34a as a potential prostate cancer therapeutic, finding limited efficacy due to low FOLR1 expression in prostate cancer cells.

The paper identifies plant traits as the main driver of core microbiomes in different root compartments and shows their distinct impacts on plant metal accumulation and growth.

This paper develops magnetic implants paired with a wearable device to wirelessly measure biophysical and biochemical signals in rats.

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

This study identifies MaUGT79 as a gene regulating scopolin biosynthesis, which enhances drought tolerance in plants through ROS scavenging and transcriptional activation by MaMYB4.

This paper introduces an automated single-nucleus RNA sequencing platform for analyzing archival glioma samples, revealing molecular characteristics and recurrence-related targets.

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

The paper identifies KEAP1 as a genetic dependency in ARID1A-deficient clear cell ovarian carcinoma cells through a genome-wide CRISPR screen, showing KEAP1 perturbation leads to growth inhibition.

The paper shows JN.1 outcompetes BA.2.86 and other variants by evading antibodies more effectively, despite reduced ACE2 binding.

The paper analyzes pseudogenes in plasmid genomes to show higher pseudogene density compared to chromosomes and links non-functionalization to loss of plasmid mobility.

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

The paper shows that HIV-1 MPER-targeting antibodies generated by vaccines lack structural constraints needed to access the MPER, despite having bnAb-like paratopes.

This paper develops an in-vivo method to engineer tumor-targeting NK cells using CARs that rely on NK receptor biology for specificity and function.

The paper identifies 586 genes up-regulated during stomata maturation using single-cell RNA-seq data and shows two TFs regulate guard cell size and function.

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

This study identifies that SARS-CoV-2 spike protein induces cytokine release syndrome by enhancing T cell production of IL-2, which drives inflammatory cytokine release through TLR4 and NF-κB activation.

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

This study evaluates the use of precision-cut liver slices (PCLS) to detect and quantify antifibrotic responses to erlotinib in murine and human cirrhosis models.