Y. Yang

This study uses DEER spectroscopy to show that a homo-dimeric protein complex is destabilized in human cells compared to solution, challenging excluded volume crowding theory.

This study shows dietary propionate causes intestinal oxidative stress in zebrafish by inhibiting SIRT3-mediated SOD2 depropionylation, leading to gut microbiota changes.

This paper shows that HBV uses aerobic glycolysis to support its biosynthesis by interacting with PKM2, and that restoring PKM2 activity can reduce viral production and oncogenesis.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study examines the interannual variability of net ecosystem carbon production in a rain-fed maize ecosystem, identifying climatic and biotic factors influencing carbon dynamics from 2005 to 2018.

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

The paper investigates gene tree discordance in Amaranthaceae s.l. using multiple methods, finding that ancient hybridizations and rapid lineage diversification may contribute to the discordance.

The paper revisits the relationship between carbon isotope discrimination and water use efficiency, showing that mesophyll conductance significantly affects predictions of intrinsic water-use efficiency.

This study identifies calumenin (CALU) as a marker of poor prognosis in glioma, showing its association with epithelial-mesenchymal transition and malignant phenotypes.

This paper shows that recombinant Bacillus subtilis spores expressing H. contortus GAPDH protect sheep from infection by boosting immune responses and reducing parasite burden.

This study identifies IKBIP as an EMT-related biomarker associated with poor survival in glioma, showing its correlation with aggressive phenotypes and key EMT markers.

The paper reports a chemoproteomic analysis of cysteine reactivity in HLRCC cells upon FH rescue, revealing transcriptional and posttranslational regulation of cysteine residues.

This paper uses native mass spectrometry to study how heparin disrupts the SARS-CoV-2 spike protein's interaction with ACE2, providing insights into its potential as a repurposed therapeutic for COVID-19.

This study evaluates 1403 FDA-approved drugs for SARS-CoV-2 inhibition using pseudovirus and authentic virus assays, identifying four compounds with potent effects and a synergistic combination.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study examines how climate change and tire wear particle leachate affect plant-microbe interactions in duckweed, showing that these stressors can alter mutualistic relationships and modify each other's impacts.

This study identifies that mammalian ATG9s bind to LC3 via UIM-UDS interaction to drive autophagosome formation.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This paper introduces PrismNet, a deep learning model that uses in vivo RNA structures to predict protein-RNA interactions and identifies disease-associated mutations affecting these interactions.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This paper introduces a fluorogenic DNA-PAINT probe that reduces background and increases imaging speed for 3D whole-cell DNA-PAINT.

A hidden layer of host immunity against non-pathogenic microbes leads to plant incompatibility with beneficial rhizobacteria.

This study identifies redundant cytokine signals, particularly IL-6, IL-21, and IL-23, that drive Th17 cell differentiation in mesenteric lymph nodes induced by segmented filamentous bacteria.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

This study uses single-cell RNA sequencing to identify zone-specific transcriptomic changes in liver sinusoidal endothelial cells in cirrhosis, revealing Zone 3 LSECs as most susceptible to damage.

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.