Y. Yang

This study identifies WhiB7-dependent and -independent pathways in M. abscessus antibiotic resistance, revealing gene regulators and resistance mechanisms.

This study identifies curved adhesions as a new type of integrin-mediated adhesion that forms in soft matrices and is crucial for 3D cell migration.

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

This paper develops two duplex qPCR systems to specifically detect and differentiate Xanthomonas translucens pathovars translucens and undulosa in wheat and barley.

This study shows that a lactobacilli-based live biotherapeutic reduces neutrophilic inflammation and improves lung function in models of BPD and COPD.

This study identifies two gH mutations (H789Y and S830N) that partially restore HSV-1 entry function when paired with specific gB variants, suggesting functional interaction sites between gH/gL and gB.

This study shows ANGPTL4 promotes epidermal stem cell proliferation and migration, enhancing wound re-epithelialization in mice.

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

The paper introduces a pillar/perfusion plate for dynamic 3D cell culture, improving growth, reproducibility, throughput, and user friendliness compared to static methods.

This study characterizes small immune complexes formed by PF4, heparin, and HIT antibodies using native mass spectrometry, revealing their structure and platelet-activating properties.

This study identifies BilR, a gut microbial enzyme that reduces bilirubin to urobilinogen, and shows its prevalence in healthy adults and decline in neonates and IBD patients.

This study investigates how the weakly electric fish Eigenmannia virescens adapts to destabilizing dynamics through sensorimotor retuning, finding improved tracking performance, reduced sensitivity to disturbances, and enhanced stability.

This study investigates how zinc affects the structure and function of TIA1 nucleic acid complexes, showing zinc induces conformational changes and reduces nucleic acid accessibility.

This paper introduces TSD, a Transformer-based model for seizure detection in EEG signals, achieving 92.1% AUROC on the TUH dataset.

This study uses adaptive optical two-photon fluorescence microscopy to image ocular lens cellular organization in vivo, revealing novel structures and growth dynamics previously unseen in dissected lenses.

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

This paper shows that organisms use mode-switching strategies to balance exploration and exploitation based on sensory salience, with implications for robotics.

This study creates a CD36 humanized mouse model to evaluate CD36-targeting therapies, showing that anti-CD36 antibodies inhibit tumor growth.

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

This study identifies LptM as a conserved lipoprotein that facilitates oxidative maturation of the LPS translocon by mimicking LPS binding, enabling efficient disulfide bond formation in LptD.

This paper develops a biomimetic human lung alveolar interstitium chip that improves epithelial barrier function and extends longevity beyond eight weeks.

This study identifies SADR1 as a TIR-containing receptor that modulates RNL-driven immune signaling in Arabidopsis, revealing TIR domains' broader roles in immunity beyond EDS1-dependent pathways.

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This study uses automated hyperspectral imaging to classify nitrogen treatments and predict leaf nitrogen content and carbon-to-nitrogen ratio in rice with high accuracy.

The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.

This study identifies heterotrophic bacteria as key drivers of sulfur oxidation in coastal sediments and seawater by analyzing microbial communities and metagenomes.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.