Y. Yang

The paper identifies a new class of T7SS effector, TslA, with a reverse domain arrangement and describes its secretion mechanism and functional properties.

The paper shows that actin-driven membrane protrusions create nanotopographies that enable stable integrin adhesion in Drosophila muscle attachment sites.

This study identifies NERCLIN as a mitochondrial protein that regulates cardiolipin homeostasis and ultrastructure, with implications for stress-induced mitochondrial adaptation.

The paper links traditional medicinal use with plant apparency rather than specialized metabolite profiles in Caryophyllales.

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

This study shows that the gut pathobiont Enterococcus gallinarum induces human Th17 and IgG3 autoantibody responses linked to disease activity in autoimmune patients.

This study shows that Mn2+ enhances pAgo protein flexibility, improving catalytic efficiency and mismatch cleavage through structural changes.

This paper introduces a pseudovirus-based method to mimic SARS-CoV-2 cell-to-cell fusion and transmission, demonstrating its utility for screening inhibitors and studying variant fusogenic ability.

The paper detects ghost introgression in Carya sinensis using genomic analysis and phylogenetic methods, revealing introgression from an extinct lineage.

This paper describes an insulin analog with an internal diselenide bridge that maintains native function and stability, potentially improving insulin shelf life and accessibility.

This study shows that tumor-derived exosomal miR-222-3p activates fibroblasts to promote renal cancer progression by inducing metabolic changes and cytokine secretion.

This study shows that different maize genotypes influence the structure of microbial and viral communities in their rhizobiome, with significant differences in viral and microbial abundance and gene content between genotypes.

This study identifies scattered genetic divergence across the genome in sympatric Brachypodium stacei populations adapting to contrasting environments with ongoing gene flow.

The paper develops a high-throughput bioluminescence assay to measure T7SSb-dependent protein secretion in S. aureus and identifies three accessory proteins required for TspA secretion.

This study identifies HDAC4-mediated deacetylation of GSDMD as a mechanism to inhibit pyroptosis by preventing GSDMD ubiquitination.

The paper presents cryo-EM structures of Kv1.2 potassium channels in different states, revealing new insights into selectivity filter stability and toxin block mechanisms.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

The paper shows stem cells can temporarily act as phagocytes to clear dead cells, regulated by lipids and retinoids to maintain tissue health.

This study shows that copy-back viral genomes (cbVGs) induce cellular stress responses, including stress granules and translation inhibition, during RSV and parainfluenza virus infections, which reduce viral protein expression without affecting antiviral immunity.

The paper discovers new anammox bacteria in aquifers, expands taxonomic diversity, and highlights their role in nitrogen cycling.

The paper discovers a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathways using advanced imaging techniques in mice.

This study uses phylogenomic data to show widespread gene flow and reticulation during the early radiation of oaks and related genera.

This study establishes the Pig Virome Database (PVD) by mining global metagenomic data, revealing extensive viral diversity and functional potential in the pig gut.

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

The paper shows amoeboid cells, like T cells and neutrophils, can durotax by polarizing NMIIA towards softer substrates, and this behavior is conserved in Dictyostelium.

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

This study uses single-cell transcriptomics to analyze human intracranial aneurysm tissue, identifying immune cell features linked to aneurysm rupture.

The paper identifies three small proteins that facilitate the export of an antibacterial nuclease via the type VIIb secretion system in Staphylococcus aureus.

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.