Y. Zhang

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

The paper compares the tumor-repressing effects of TCF11 and Nrf1, showing TCF11 is more potent, while both have similar regulatory profiles distinct from Nrf2.

This study identifies how Mycoplasma ovipneumoniae evades alveolar macrophage clearance by altering apoptosis, phagosome maturation, and autophagy in sheep.

This study shows that a Wolbachia transinfection (wAlbBQ) remains stable in different Aedes aegypti backgrounds and exhibits consistent phenotypic effects.

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study investigates the differential and cooperative roles of Nrf1 and Nrf2 in regulating antioxidant gene expression and cytoprotective responses to tBHQ-induced oxidative stress in human cell lines.

This paper introduces CHAMP, a computational microscopy method for high-throughput, label-free histological imaging, and demonstrates its ability to generate virtually stained images through unsupervised learning.

This paper develops a RPA-Cas12a fluorescence assay for rapid, accurate detection of zoonotic dermatophytes with high sensitivity and specificity.

The paper identifies DRAIC, a tumor suppressive lncRNA, which inhibits NF-kB and activates AMPK-mTOR pathways to suppress cancer progression.

This study identifies RNF213 as an ISG15-interacting sensor that detects ISGylated proteins and exhibits broad antimicrobial activity against multiple pathogens.

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

This study identifies pheromone receptors in Cnaphalocrocis medinalis that enable it to detect conspecific and heterospecific pheromones, aiding in avoiding competition in rice fields.

This study examines how nitrification inhibitors and straw incorporation affect N2O emissions and microbial communities in different cropland soils, finding that their effects vary by soil type.

The paper shows that microtubules inhibit miR165/6 loading into AGO1 in the cytoplasm, enabling its non-cell autonomous movement in Arabidopsis roots.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This study shows TIR signaling enhances the interaction between EDS1/PAD4 and ADR1-L1 and promotes ADR1-L1 oligomerization, crucial for immune activation and cell death.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.