Y. Zhang

This study investigates how specific amino acids in the DNA-binding domain of CcpA affect carbon source utilization in Bacillus licheniformis through in vitro and in vivo experiments.

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

The paper identifies Ola1p as a positive regulator of heat shock response in yeast through proteomics and cell-based assays, showing its role in stabilizing misfolded proteins and facilitating translation resumption after stress.

This study identifies ABCG17 and ABCG18 as ABA importers that redundantly regulate ABA homeostasis and translocation in Arabidopsis, affecting stomatal closure and root development.

This study shows that bacteriophages adapt to the mammalian gut mucosa through mutations and recombination, gaining a fitness advantage by altering their binding to mucin glycans.

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.

This study shows that MYC-driven immune evasion in TNBC can be reversed by combining immunotherapies, leading to tumor regression in mice.

This study identifies the VE-cadherin/AmotL2 mechanosensory pathway as a suppressor of aortic inflammation and abdominal aortic aneurysms through mechanotransduction in endothelial cells.

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

This study identifies MARCH8 as an antiviral factor that ubiquitinates and degrades viral envelope glycoproteins by targeting their cytoplasmic lysine residues.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

The paper examines the relationship between mangrove forest fragmentation and salt marsh invasion magnitude across a climatic gradient in southeast China.

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

This study shows CBP60b positively regulates SNC2-mediated immunity in Arabidopsis by enhancing SARD1 expression and is required for TIR signaling.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

The paper identifies promoter sequence determinants and structural basis of primer-dependent transcription initiation in E. coli using MASTER and biochemical studies.

This study identifies Rab11a as a critical host factor for influenza A virus genome assembly by facilitating vRNP congregation and specific interactions.

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

This paper identifies RORC2 as a key host factor that promotes HIV-1 gene expression and viral outgrowth in Th17 cells, suggesting it as a new therapeutic target.

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.