Y. Zhu

This paper develops a combined proteomic workflow to enable deep spatial proteome profiling of small tissue samples, achieving over 5,000 protein quantifications from a human pancreatic tissue pixel.

The paper fits a simple telegraph model to complex gene expression models to infer effective parameters and reveal underlying regulatory mechanisms using single-cell data from E. coli and mammalian cells.

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

This study identifies diagnostic SNPs for FOV4 resistance in Upland cotton and finds that specific SNP genotypes correlate with reduced vascular discoloration.

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

The paper isolates ACE2-dependent and -independent sarbecoviruses from Chinese horseshoe bats using a new virus isolation protocol.

The paper reports a new polymerization pathway for novel oligomeric flavonoids called papanridins in plants and identifies a flavanol polymerase gene involved in their biosynthesis.

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

The paper identifies conserved gene regulatory networks in superrosid species for root epidermal cell patterning, showing Type III species inherited the network while Type I species evolved through mutations.

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

The paper identifies 111 proteins enriched in bacterial RNP bodies (BR-bodies) and shows they form a complex network of protein-protein and protein-RNA interactions that regulate BR-body phase separation and RNA processing.

This study shows that engineering anthocyanin pathway in Artemisia annua cells does not prevent artemisinin biosynthesis, suggesting artemisinin can be produced in non-GT cells.

This study develops a sensitive top-down proteomics method to analyze large proteoforms in single muscle cells, revealing heterogeneity and linking it to muscle fiber types.

This study examines how early-season herbivory affects plant development and reproduction across four Brassicaceae species, finding that effects are mediated through plant development rather than direct herbivore pressure.

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

The paper examines NLR sequence diversity in rice landraces and modern varieties, finding higher diversity and balancing selection in landraces, suggesting their value for disease resistance.

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

The paper shows that BR signaling is attenuated in stomatal precursor cells but remains active in differentiating epidermal cells, mediated by scaffold proteins.

The paper maps immunocyte migration from the gut using single-cell genomics and a photoconvertible mouse model, showing lineage-specific emigration patterns and their influence on peripheral immunity.

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

The paper investigates how environmental stress during larval development affects DNA methylation in the painted lady butterfly, identifying epigenetic shifts linked to environmental conditions and gene expression patterns.

The paper discovers a new aphid-transmitted rice virus, RTIV, from wild rice plants and shows it causes low-tillering disease in rice cultivars.

This study uses simulations to show that TADE suppression gene drives are more confined in continuous space and can suppress populations effectively under certain conditions.

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.