Z. Hu

This study evaluates the neutralization of SARS-CoV-2 501Y.V2 variant by antisera from two Chinese vaccines, showing preserved neutralizing titres against the variant.

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The paper develops a genomic resource of 1,500 soybean genomes with 32 million SNPs to enable post-genomic research and applications like QTL discovery and trait allele identification.

The paper identifies ARID1A deficiency's role in promoting pancreatic tumorigenesis by reducing KRAS-induced senescence through upregulation of ALDH1A1 in mouse PanIN models.

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

This study develops TRAFTACs, chimeric oligonucleotides that degrade transcription factors via proteasomal pathway, and demonstrates their effectiveness on NF-κB and brachyury.

The paper characterizes a clinical Enterobacter hormaechei strain co-carrying blaNDM-1, blaIMP-4, and mcr-9.1, highlighting the convergence of resistance genes in an epidemic clone.

This study evaluates how different tools and parameters affect microbial co-occurrence network inference from 16S amplicon data and develops a standardized pipeline.

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study isolates multiple SARS-CoV-2-neutralizing antibodies through site-directed screening, showing potent protection against virus infection.

This study analyzes exome sequencing data from paired primary tumors and metastases to investigate clonality and timing of metastatic spread across cancers.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This study investigates the PK/PD relationship of tilmicosin against M. hyopneumoniae, identifies resistance mechanisms, and suggests optimal dosing regimens.

This study shows that Nrf2 represses ER stress-related ferroptosis in renal carcinoma cells through the HO-1 pathway, suggesting it as a potential therapeutic target.

This study identifies cinnamoyl-CoA reductases (CCR) as benzaldehyde synthases in cucumber, showing their specific expression and enzymatic activity in roots and flowers.

This study identifies genetic variants in sorghum associated with resistance to the parasitic weed Striga hermonthica, revealing balancing selection and tradeoffs in resistance mechanisms.

This paper proposes a strategy to select crop varieties based on yield factors and meteorological predictions, showing 70% and 50% success rates in two pilot regions for soybean variety selection.

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

This paper reports on the use of Neo-Islets in pet dogs to treat insulin-dependent diabetes, achieving improved glycemic control without immunosuppression or encapsulation.

This paper introduces PhyloAcc, a Bayesian method to detect substitution rate changes in conserved noncoding elements across phylogenies, showing improved accuracy over existing methods in identifying rate shifts associated with convergent phenotypes.

This study shows that FADD is critical for intestinal intraepithelial lymphocyte (IEL) development, particularly affecting CD8αα+ TCRγδ+ T cells, and its loss worsens colitis.

This paper constructs a synthetic inducible promoter by analyzing the 39K promoter of BmNPV and identifies key regulatory regions for virus-inducible activity.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

This study shows that convergent flightlessness in palaeognathous birds is associated with regulatory changes rather than protein-coding gene evolution.

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

The 10,000 Immunomes Project provides a diverse human immunology reference from 44,000 individuals, enabling analysis of immune variations by age, race, and sex, and serving as a common control for immunological studies.