Z. Li

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

The paper analyzes mutation spectra and compositional variability in SARS-CoV-2 clades to understand mutation patterns and their implications for viral proteomes.

The paper identifies mutanofactin-697, a secondary metabolite from S. mutans, which promotes biofilm formation by increasing bacterial hydrophobicity and adhesion.

The paper analyzes amino acid occurrence differences between vertebrates to show thermoadaptation correlates with protein solvation more than dynamics.

This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

This paper evaluates a prefusion-stabilized SARS-CoV-2 Spike protein vaccine candidate, Ad26.COV2.S, showing potent neutralizing and Th1-polarized immune responses in mice.

This study shows retinoic acid reprograms enhancer landscapes in MYCN-amplified neuroblastoma cells, downregulating MYCN and inducing sympathetic differentiation.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

The paper introduces a protein-based assay to detect neutralizing antibodies against SARS-CoV-2, showing it correlates with traditional viral neutralization tests.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

This study identifies replication stress and FOXM1 as drivers of radiation-induced genomic instability and cell transformation in human cells.

This study identifies the PacC-dependent pH signaling pathway in the rice blast fungus Magnaporthe oryzae, showing it regulates host pH changes and the switch between biotrophic and necrotrophic growth, essential for disease development.

This paper introduces SAMPEI, a spectral alignment method for detecting protein modifications using high-resolution mass spectrometry, demonstrating its effectiveness in identifying sub-stoichiometric modifications in mouse macrophages.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

This study shows that cancer cells rely on environmental lipids for proliferation under conditions of limited electron acceptors, such as hypoxia or mitochondrial inhibition.

The paper uses molecular markers and ecological niche models to study introgression between Betula tianshanica and Betula microphylla, finding bidirectional gene flow with implications for conservation.

The paper describes synthetic monoclonal antibodies that neutralize SARS-CoV-2 by binding to the spike protein and blocking ACE2 receptor interaction, showing potent antiviral activity.

This study shows that intestinal FGF15 protects against muscle and bone loss after sleeve gastrectomy in mice.

This paper introduces a high-throughput microfluidics system for perfusion and validates its use in long-term all-optical electrophysiology of human cells.

The paper shows closed microbial communities of algae and bacteria self-organize to robustly cycle carbon through emergent metabolite exchange.

This study shows that blood collection tubes affect biomarker screening results in mass spectrometry, with coagulant tubes altering protein profiles and reducing biomarker detection.

This study shows that S-enantiomers of chloroquine and hydroxychloroquine are more effective against SARS-CoV-2 and less toxic than their R-enantiomers, suggesting S-HCQ as a better treatment option for COVID-19.

The paper identifies a novel activation switch loop in Plexin-B1 that enhances its GAP activity towards Rap1b through a cooperative mechanism involving conformational changes.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.