Z. Lin

This paper develops photo-lenalidomide, a modified lenalidomide probe, to identify cellular targets using chemical proteomics, revealing new targets like eIF3i.

This paper introduces a cyborg brain organoid platform for long-term 3D electrophysiological recording, enabling continuous monitoring of single-cell action potentials during brain organoid development.

This study shows that expressing SARS-CoV-2 Spike S1 subunit in cardiomyocytes causes cardiac hypertrophy and inflammation via TLR4 activation, independent of ACE2.

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

The study identifies HLD1, an ortholog of PGAP1, as essential for Papaver self-incompatibility through GPI-anchor remodeling.

The paper provides evidence that the death domain of the p75 neurotrophin receptor exists in equilibrium between monomeric and dimeric forms in solution.

This paper introduces a method to recognize small biomolecules through dose-effect interdependence encoded in chromatographic microassay arrays, applied to natural products for high-throughput screening.

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

This study builds a human walking kinematic model combining lower limb rolling-foot and upper limb multi-rod swinging models, showing good agreement between experimental and theoretical joint velocity calculations.

This study shows extracellular histones stimulate collagen production in liver fibrosis via TLR4-MyD88 signaling, and NAHP reduces fibrosis by neutralizing histones.

The paper introduces WIAD, an open-source tool for visual analysis of wood images to improve transparency and reproducibility in ecological studies.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

This study identifies secondary metabolite biosynthetic pathways in shipworm symbionts using metagenomes and cultured genomes, showing many novel pathways and predictable host-symbiont co-occurrence patterns.

This paper introduces hydrazine-based chemoproteomic probes to target cofactor-dependent enzymes, enabling enzyme discovery and drug development through diverse functional profiling.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

This study shows Mg2+ promotes bone regeneration initially by modulating macrophage activity but later inhibits bone formation through NF-κB activation and reduced hydroxyapatite precipitation.

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

The paper shows that RbAp46/48LIN-53 and HAT-1 are essential for initial CENP-AHCP-3 deposition and de novo centromere formation on artificial chromosomes in C. elegans embryos.

The paper investigates DNA sequence preferences for de novo centromere formation on artificial chromosomes in C. elegans, finding that AT-rich sequences, not repetitiveness, accelerate centromere formation.

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

This study identifies stem cell-like GBM cells outside the contrast-enhancing region and proliferative lymphocytes in GBM patients' blood, linking them to recurrence and immunotherapy.

This study identifies SURF4 as an ER cargo receptor that facilitates EPO secretion and suggests its modulation could treat erythropoiesis disorders.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

The paper shows animals can synthesize complex polyketides, previously thought to be microbial, through a symbiotic partnership with chloroplasts.

This study investigates the duplication and maintenance of ribosomal protein genes in fungi, finding parallel concerted evolution and adaptive advantages in sugar-rich environments.

This paper introduces cyborg organoids with embedded nanoelectronics that monitor electrophysiology during organogenesis in human cardiac organoids.