Z. Yu

This study shows PRMT7 inhibition enhances anti-tumor immunity and improves response to immune checkpoint blockade in melanoma by modulating immune cell infiltration and PD-L1 expression.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

This study identifies KPNB1 and RUVBL2 as key regulators of NFAT5's unconventional tonicity-dependent nuclear trafficking.

This paper introduces a millimeter-sized wireless implant for endovascular nerve stimulation, demonstrating its ability to target peripheral nerves with minimal invasiveness and reduced risk compared to traditional methods.

The paper shows that PLK-2 inactivates CHK-2 in C. elegans to promote crossover formation and meiotic progression after synapsis.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

This study shows miR-34c suppresses osteosarcoma progression by targeting Notch and E2F pathways, improving survival in mouse models and correlating with better patient outcomes.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

This study shows HDAC6 suppresses HCCLM3 cell migration and invasion by downregulating TGF-β1 and inhibiting EMT.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.

The paper shows that centromere linkage to the SPB drives redistribution of Sad1 and Plo1 activation, facilitating partial NEBD and spindle formation in fission yeast.

The paper evaluates the effect size, sample size, and power of Forced Swim Test assays in mice, finding large effect sizes and recommending increased sample sizes for reliable results.

The paper quantifies the reduction of antibiotic resistance genes during urban sewage conveyance and treatment, showing greater removal occurs during conveyance than treatment.

This paper introduces PlantU-net, an end-to-end segmentation network for maize seedling phenotyping from top-view images, achieving high accuracy with minimal training data.

This study shows that convolutional neural networks can enhance SNR and generate contrast in cryo-EM images, improving image processing outcomes.

The paper shows H2A.Z, independent of SWR1, associates with the LINC complex at meiotic telomeres and centrosomes, promoting chromosome motion during meiosis.

The paper uses cryo-ET to determine the 7 Å structure of the AcrAB-TolC efflux pump in Escherichia coli, revealing its activation mechanism through interprotein interactions.

The paper reports Cryo-EM structures of hEAAT3 in different functional states, revealing an elevator mechanism for glutamate transport and conserved sodium-substrate coupling.

The paper shows CDK enforces Spc72 asymmetric docking and regulates nucleation site balance in yeast SPB duplication.

This study identifies potential mechanisms of celastrol's anti-inflammatory effects in rheumatoid arthritis by analyzing transcriptomic and proteomic changes in fibroblast-like synoviocytes.

This study investigates how Duox and TLR3 genes in Hermetia illucens larvae suppress zoonotic pathogens by modulating intestinal bacterial community homeostasis through immune signaling pathways.

The paper develops a high-throughput method for implanting microdevices into brain and soft tissues using microneedles and evaluates its precision and tissue impact in agarose and rat cortex.

The paper introduces molecular goniometers using DNA origami to precisely orient DNA-binding proteins for cryo-EM, achieving a 6.5 Å structure of BurrH.

This study shows that heme impairs alveolar epithelial sodium channels, contributing to pulmonary edema after halogen gas inhalation.

This study identifies genes that tumor cells use to resist T cell killing and shows that inhibiting BIRC2, ITGAV, or DNPEP enhances T cell-mediated tumor destruction.

The paper shows that ATPase binding at one end of the 20S proteasome allosterically opens the opposite gate, promoting symmetric and asymmetric proteasome configurations.

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.