Z. Yu

This study models phage-bacteria interactions to predict the potency and longevity of phage cocktails against Pseudomonas aeruginosa.

The paper investigates how the HD domain of LdCsm DNase is activated by remodeling a tripartite substrate-binding motif through RNA-induced structural changes.

This paper determines the dimer and tetramer structures of human UBR5, revealing its oligomerization mechanism and functional implications for cancer.

This study investigates how Nrf2 loss affects senescence and cognition in P301S tauopathy mice, finding that Nrf2 protects brain function through mechanisms beyond senescence inhibition.

The paper identifies novel sperm proteins in mammals using cryo-electron tomography and AlphaFold2 models, revealing their structural roles in flagellar mechanics.

This study shows low molecular weight hyaluronan inhibits lung epithelial ion transport by activating the calcium-sensing receptor, with effects reversed by a CaSR inhibitor or high molecular weight hyaluronan.

This paper shows SARS-CoV-2 Orf3a is not an ion channel but interacts with trafficking proteins, while SARS-CoV-1 Orf3a does not.

This study identifies Tmem100 as a lung-specific endothelial gene through single-cell RNA-sequencing analysis.

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

The paper introduces a new NanoBRET assay to study agonist interactions with PTHR1, revealing kinetic and thermodynamic insights into ligand binding and activation.

This paper introduces methodologies to optimize the design and alignment of telecentric digital holographic microscopes by determining the optimal +1 order position, verified using living HeLa cells.

This study investigates how multivalent binding of dynein light chains regulates the interactions of dynein intermediate chain with dynactin and NudE, revealing autoinhibition caused by intramolecular interactions.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

This study uses cryo-electron tomography to reveal the asymmetric protein complexes in mammalian sperm axonemes, explaining their unique flagellar beating pattern.

This paper introduces a core-shell microgel bioprinting method to create functional living materials with controlled microporosity and enhanced bioprocessing capabilities.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

This paper develops a quantum machine learning method for diagnosing COVID-19 using patient data and shows it can efficiently and accurately classify cases.

The paper introduces Yn situ, a single RNA molecule in situ detection method, showing it is sensitive and quantitative for gene expression in mouse olfactory epithelia.

The paper uses cryo-ET to identify structural changes in platelets during pre-acute myeloid leukemia, suggesting these changes could serve as an early diagnostic biomarker.

This study shows Senataxin and RNase H2 work together to remove R loops and prevent genome instability during class switch recombination.

The paper shows DNA damage response signaling stabilizes cohesin and promotes meiotic chromosome axis formation in C. elegans by downregulating WAPL-1 through ATM-1 phosphorylation.

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.