Wiepke Cahn

Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes

This study links sulcal widening in schizophrenia to network hubs and genes involved in synaptic signaling and energy metabolism.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia

The paper uses brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia and identifies enriched networks and genes associated with the disease.

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

Longitudinal allometry of sulcal morphology in health and schizophrenia

The paper examines longitudinal allometric scaling of sulcal morphology in health and schizophrenia, finding steeper age-related declines in SZ compared to healthy individuals.

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

This study identifies sex-dependent genetic risk loci shared and specific to mood and psychotic disorders using genome-wide interaction analysis.

Sex differences in lifespan trajectories and variability of human sulcal and gyral morphology

The paper examines sex differences in lifespan trajectories and variability of human sulcal and gyral morphology using longitudinal neuroimaging data.

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

The paper compares ten polygenic score methods for psychiatric disorders across multiple cohorts, finding that some methods significantly improve prediction statistics over the baseline PC+T method.

Dissimilarity in sulcal width patterns in the cortex can be used to identify patients with schizophrenia with extreme deficits in cognitive performance

The paper identifies a subgroup of schizophrenia patients with extreme cognitive deficits by analyzing sulcal width dissimilarity using the PBSI-SW metric.

Changes in the intracranial volume from early adulthood to the sixth decade of life: A longitudinal study

This study reports longitudinal changes in intracranial volume (ICV) from early adulthood to the sixth decade, finding increases until the fourth decade followed by decreases, with cross-sectional results showing larger changes.

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

Evolutionarily developed connections compromised in schizophrenia

The paper examines how evolutionary changes in human brain connectivity overlap with schizophrenia-related changes, finding that human-specific connections are more involved in schizophrenia pathology.

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

The paper identifies shared disconnectivity patterns in central brain pathways across twelve psychiatric and neurological disorders using a meta-analytic connectome study.

Age at first birth in women is genetically associated with increased risk of schizophrenia

The paper finds a genetic association between schizophrenia risk and age at first birth in women, with different genetic correlations in younger and older age groups.

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

This study compares LDSC and GREML methods for estimating genetic correlation, showing GREML provides higher accuracy, especially in the presence of genetic heterogeneity.

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

This study identifies eight genome-wide significant CNV loci associated with schizophrenia using a large cohort of 41,321 subjects.