Louise Chang Laurent

Asthma Exacerbations: Integrative Analysis of miRNA Activity Using Single-Cell Transcriptomics

The paper identifies cell types regulated by circulating miRNAs linked to asthma exacerbations using scRNA-seq and validates findings in GEO datasets.

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

Macrophage Polarizations in the Placenta and Lung are Associated with Bronchopulmonary Dysplasia

This study investigates the relationship between placental and lung macrophage polarization and their role in the development of bronchopulmonary dysplasia.

Molecular signatures associated with successful implantation of the human blastocyst

The paper identifies molecular signatures in human blastocysts associated with successful implantation by analyzing gene expression and cell-cell interactions in embryos with different morphological grades.

Discovery and Verification of Extracellular microRNA Biomarkers for Diagnostic and Prognostic Assessment of Preeclampsia at Triage

This study identifies and validates three bivariate extracellular miRNA biomarkers for early diagnosis and subtype distinction of preeclampsia using maternal serum samples.

Sentinel Cards Provide Practical SARS-CoV-2 Monitoring in School Settings

This paper tests cleaning solutions for sentinel cards to improve temporal resolution of SARS-CoV-2 monitoring in schools by distinguishing new infections from persistent viral traces.

Gene regulatory networks underlying human microglia maturation

This study defines age-specific brain environmental factors driving microglia phenotypes through transcriptomic and epigenomic analysis of human fetal and postnatal microglia.

Comparison of miRNA profiling methods using synthetic miRNA pools and standardized exRNA samples reveals substantial performance differences

This study compares miRNA profiling methods using synthetic pools and exRNA samples, finding significant differences in reproducibility, accuracy, and sensitivity across platforms.

Accuracy, Reproducibility And Bias Of Next Generation Sequencing For Quantitative Small RNA Profiling: A Multiple Protocol Study Across Multiple Laboratories

This study evaluates the accuracy, reproducibility, and bias of small RNA-seq across five protocols and nine labs, finding protocol-specific bias that can be mitigated with adapters and computational corrections.