Henning Urlaub

This study identifies RpaB as a light-and redox-responsive transcription factor regulating a type III-Dv CRISPR-Cas system in Synechocystis sp. PCC 6803 and shows CrhR interacts with the leader transcript posttranscriptionally.

This study identifies phosphorylation-dependent interactions between VAPB and ELYS that facilitate nuclear envelope formation during mitosis.

This study determines the structure of archaeal RNA polymerase and its interaction with Spt4/5, revealing conformational changes and a DNA-binding role for Spt5.

The paper identifies RnpM (YlxR) as a novel modulator of RNase P activity in B. subtilis, reducing its ability to process pre-tRNAs.

This study uses transcriptomics and proteomics to analyze the thermal stress response in Pyrococcus furiosus, revealing rapid transcriptome reprogramming and persistent protein upregulation during heat shock.

The paper identifies phosphatases rapidly modified by luteinizing hormone in ovarian follicles, revealing their role in regulating NPR2 guanylyl cyclase dephosphorylation.

The paper identifies SPPL3 as a gene that enables tumor cells to evade NK cell lysis by altering N-glycan structures, and shows that inhibiting N-glycan maturation restores NK sensitivity.

This study determines the structural basis of RNA polymerase II initiation at snRNA promoters using SNAPc, revealing its role in DNA opening and transcription initiation independent of TFIIE and TFIIH.

The paper identifies primate-specific CAMK2B splice variants regulated by branch point weakening, showing their role in long-term potentiation and learning.

The paper characterizes conformational changes in human 48S translation initiation complexes during start codon recognition using cryo-EM and kinetic methods.

The paper uses proteogenomics to assess CUG codon mistranslation in Candida albicans and finds no evidence of leucine mistranslation, instead showing ribosomal-level ambiguity and no correlation with pathogenicity.

This study compares the release and effects of alpha-synuclein, Tau, and huntingtin in neuronal cells, showing similar release pathways and impacts on neuronal activity and inflammation.

The paper shows that a small population of synaptic vesicles contain different neurotransmitter transporters, enabling corelease of various neurotransmitter combinations.

The paper characterizes ectosomes and exosomes proteomes and shows they modulate neuronal activity differently.

This study defines the molecular mechanism of GTPase-mediated mitochondrial ribosome biogenesis and recycling using cryo-EM and biochemical approaches.

The paper identifies transient deSUMOylation of IRF2BP proteins as critical for regulating immediate early gene expression in EGFR signaling.

The paper determines the structure of the yeast RSC chromatin remodeller bound to a nucleosome, revealing mechanisms of nucleosome sliding and implications for human SWI/SNF complexes and cancer.

The paper identifies PKCα-dependent interactions between otoferlin and calbindin in inner hair cells, suggesting a role in regulating endocytosis through Ca2+-dependent signaling complexes.

The paper identifies Kir4.1 and Connexin43 as Nedd4-2 substrates, showing their regulation impacts astrocytic function and neuronal network activity.

The paper determines the cryo-EM structure of the human core TFIIH-XPA-DNA complex, revealing how XPA and XPG switch TFIIH from a transcription factor to a DNA repair factor.

The paper identifies a novel sense codon reassignment in Pachysolen tannophilus, where CUG is translated as alanine instead of leucine, and proposes a tRNA loss-driven mechanism for this genetic code alteration.