Raúl Mostoslavsky

A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retina

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

NRF2 activation induces NADH-reductive stress providing a metabolic vulnerability in lung cancer

The paper shows NRF2 activation in KEAP1 wildtype lung cancers causes NADH-reductive stress, making them vulnerable to Complex I inhibition.

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.