microscopy & imaging analysis

This study investigates how ADP and magnesium influence the structural changes and higher-order assembly of peroxiredoxin 2, showing distinct roles in disassembly and reassembly processes.

The paper reports the cryo-EM structures of an Acinetobacter baumannii podovirus, revealing its capsid maturation mechanism and providing a reference for phage engineering.

The paper introduces SMAUG, a semi-automated tool for analyzing actin filament dynamics from TIRF microscopy images, reducing analysis time while maintaining accuracy.

This paper identifies a binuclear [Cu2S2] cluster in DPOR that mediates functional asymmetry between its active sites.

The paper identifies prokaryotic homologs of the major vault protein that assemble into vault nanocapsules, revealing structural and size variability.

This study shows that bL9 prevents recoding events in collided ribosomes by stabilizing their interaction and reducing frameshifting and hopping.

This study investigates how tau protein regulates motor proteins on microtubules using single-molecule imaging, cryo-EM, and MD simulations, revealing distinct mechanisms for inhibiting kinesin-1 and dynein.

This study shows FoxO1 and HNF1α work together to change nucleosome structure and stability to activate transcription.

The paper shows that nociceptive signaling is essential for the brain to represent and replay inflammatory states using human fMRI and mouse activity mapping.

This study shows that proteolytic feedback regulates quorum sensing in Pseudomonas aeruginosa by controlling RhlR stability, affecting virulence and biofilm formation.

This study combines live-cell imaging and mathematical modeling to show how cancer cells adapt to stress in spatially confined environments, revealing cooperative and competitive strategies influenced by spatial organization and microenvironment dynamics.

GraphExperiment provides an R/Bioconductor package to store and manipulate high-dimensional quantitative data alongside associated networks in a unified framework.

This study shows that sharks and rays have cartilage canals in their adult skeletons, which are vascular but do not trigger endochondral bone formation, suggesting an ancient role in nutrient transport.

The paper identifies CYLD as a host deubiquitinase recruited to Listeria monocytogenes surface via InlC and RNF213, which facilitates cell-to-cell spread in epithelial cells.

This study determines the structure of human GluD1 and elucidates its ligand-gating mechanism using cryoEM and electrophysiology.

This study identifies kinetic differences in RAS-BRAF engagement between KRAS and NRAS, showing how oncogenic mutations and inhibitor sensitivity are influenced by these dynamics.

The paper investigates nuclear wrinkles in epithelial cells, finding they form due to geometric adaptations to mechanical stress and cell shape changes, without causing damage.

The paper compares 3D vascular imaging modalities to assess their accuracy in quantitative measurements and computational modeling of vascular morphology.

This study identifies the CrdRS two-component system as a key regulator of antibiotic-induced biofilm formation in H. pylori through bidirectional control of transporters PlpA and GlnP.

This study shows that targeting catecholate siderophore systems reduces AIEC colonization in colitis by immunization, preserving gut microbiome composition.

The paper determines the Cryo-EM structure of the Arabidopsis thaliana V-type ATPase, revealing its catalytic cycle and organelle-specific interactions with TLDc proteins.

This study shows that pneumolysin, a bacterial toxin, can damage target cell membranes through vesicle fusion rather than pore formation.

This study identifies a bacterial protease that influences phage susceptibility and links it to host epithelial responses in ulcerative colitis.

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

The paper shows that MCA1 mechanosensitive channels mediate rapid inter-root signaling in Arabidopsis following mechanical injury.

This study identifies structural adaptability in HIV-2 Vif that enables broad antagonism of APOBEC3G through conformational selection.

msaGUI is a no-code tool for analyzing and visualizing multispectral images through customizable workflows and exportable outputs.

The paper uses FACS to analyze Escherichia coli L-forms and finds they maintain synchronized nucleic acid synthesis despite lacking a cell wall.

This study determines the cryo-EM structure of HIV-1 capsid lattice with lenacapavir, showing how it disrupts capsid formation and function during virion maturation.