C. elegans

This study uses proteomics to analyze early host adaptation of Candida auris in vitro and in vivo, revealing molecular adaptations during host-pathogen interaction.

The paper compares whole-brain neural activity between sexes of C. elegans in response to various chemical stimuli, finding widespread sexual dimorphism in sensory neurons.

The paper identifies SNPC-1.2 as a female-specific piRNA transcription factor in C. elegans, revealing how gene duplication and functional specialization generate sex-specific piRNA expression.

This study resolves high-resolution structures of the C. auris ribosome in complex with three inhibitors, revealing unique features that may inform antifungal therapy development.

This study identifies tyrosine phosphorylation sites on SYG-1 that drive biomolecular condensate formation, essential for presynapse assembly in C. elegans.

This study characterizes Cj MlaC's structure and function, revealing its unique monomer-dimer equilibrium and lipid-binding properties that adapt to C. jejuni's lipidome.

This study investigates the role of PRPF-4, a spliceosomal kinase, in C. elegans development and germline function, showing its essential role in alternative splicing and gene expression.

The paper shows that DAF-18/PTEN prevents tumors in C. elegans by enhancing calcium sensitivity through IIS-calcium cross-talk, reducing germ tissue turnover.

This study uses C. elegans to analyze the pharmacokinetic and pharmacodynamic relationships of gabapentinoids, showing dose- and time-dependent effects and a saturable pharmacodynamic ceiling.

The paper shows that a 70 mT static magnetic field restores mitochondrial function and reverses hyperglycaemia-induced cellular damage in C. elegans.

This study identifies SMZ-1/2 as PDZ proteins that initiate MSP filament assembly and FB-MO biogenesis in C. elegans sperm by coupling kinase signaling to organelle formation.

This study shows C. elegans uses chromoprotein photosensitization and bacterial metabolic cues to prefer red over blue food, independent of light and photoreceptors.

The paper uses gene gradients to infer directed structural connectivity across species and applies it to human data to reveal source-sink network organization.

This study identifies a novel fungal taurine biosynthetic pathway in Candida albicans, showing its role in metabolic fitness and virulence.

This study shows that the marine bacterium Kocuria rhizophila CDMP12 reduces Parkinson's disease pathology in C. elegans by suppressing ferroptosis and alpha-synuclein aggregation.

This study identifies DNA repair mechanisms that influence CRISPR-Cas antifungal efficacy in Candida albicans and shows how to tune Cas9 lethality through repair template availability and enzyme activity.

The paper shows that DNA lesions in C. elegans can be inherited and generate multi-allelic mutations across generations.

This study uses Carbotrace 480 to detect protoplasts in a pigment-deficient mutant of Chlorella sorokiniana, identifying Snailase as the most effective enzyme for cell wall degradation.

This study shows that high temperature-induced diapause in C. elegans temporarily enhances progeny dauer formation upon re-exposure to heat, while preserving reproductive capacity.

The paper identifies oxaloacetate accumulation as a cause of mitochondrial damage by inhibiting MIC60-dependent membrane remodeling in C. elegans and mammalian cells.

This study investigates heme transfer in Candida albicans using fluorescent hemophore fusions, revealing distinct kinetic mechanisms for heme acquisition and transfer between hemophores.

This study shows that loss of Pmc1p in Candida albicans increases tolerance to echinocandins by enhancing calcineurin signaling.

The paper investigates how different forms of autophagy restrict neurite outgrowth in distinct neuronal compartments in C. elegans neurons.

This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.

This study defines the hierarchical order of divisome assembly in C. difficile using CRISPRi and fluorescent fusions, revealing a unique division mechanism distinct from model bacteria.

This study identifies cmrA as a key regulator of hyperadhesion in C. crescentus chemotaxis mutants by recruiting it to the cell pole to activate PleD.

The paper develops a 4D whole-cell model of Prochlorococcus marinus MED4 to show how spatial organization and redox PTMs regulate carbon fixation under light disturbance.

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

The paper uses unsupervised machine learning to identify pyrenoid morphology mutants in Chlamydomonas reinhardtii, linking defects to CO2-dependent growth and mitotic remodeling.

This study uses MIMS-EM to analyze metabolic turnover in C. elegans during dietary restriction, revealing tissue- and resource-specific changes at multiple scales.