mouse

This study shows that caspase-1 and -11 protect against environmental pathogens but not host-adapted ones in genetically diverse mice.

The paper identifies sub-micron actin ridges on macrophages that facilitate phagocytosis of encapsulated fungal pathogens like Cryptococcus neoformans.

This study examines how delays in bushy cell axons contribute to sound localization in Mongolian gerbils, finding developmental changes in delay patterns and their impact on interaural time difference processing.

This study shows that fucoxanthin protects mouse oocytes from postovulatory aging by activating NRF2 in cumulus cells, improving mitochondrial function and reducing oxidative stress.

This study shows that CBD reduces glucagon secretion in mouse αTC1-6 cells by altering lysosomal trafficking and secretion pathways.

This study shows that nucleus accumbens acetylcholine dips track reward value and delay, influencing adaptive choice in mice during delay discounting tasks.

This study shows JAK1/2 inhibition reduces pathogenic immune responses and restores tissue integrity in chronic skin inflammation by shifting immunity toward IL-17 responses.

This study identifies TREM2's role in atherosclerosis regression by enhancing efferocytosis in lipid-experienced macrophages, suggesting TREM2 as a therapeutic target for plaque stabilization.

The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.

The paper identifies MIRINE, a small ORF-encoded polypeptide that promotes neuronal differentiation in vertebrate brain development by regulating the balance between proliferation and maturation.

This study evaluates cell-specific activity of antisense oligonucleotide conjugates in vivo using a reporter mouse model and finds that palmitate conjugation shows broad extrahepatic activity and preferential skeletal muscle targeting.

This study shows that fertilization can reverse the negative effects of maternal age on oocyte quality in mice, provided the fertilization environment is not aged.

This study examines how PFOS and GenX affect mitochondrial respiratory complex activities in liver and brain under different exposure conditions, showing exposure-dependent and tissue-specific effects.

This study evaluates an mRNA vaccine encoding CagW, a component of H. pylori's type IV secretion system, showing it protects mice against bacterial challenge.

This study examines how predator-associated chemosignals influence risk assessment behaviors and vomeronasal neuron activity in mice, revealing distinct spatiotemporal patterns and neural responses to different predator cues.

In a mouse branch retinal vein occlusion model, retinal ganglion cells die progressively over 14 days. α-RGCs and F-RGCs are lost fastest, and TBR2-positive intrinsically photosensitive RGCs survive best.

This study shows mast cell-derived histamine suppresses hematopoietic stem cell function, as evidenced by increased hematopoiesis in histamine-deficient mice and reversal with exogenous histamine.

Hypo-fractionated FLASH and conventional radiotherapy (3x10 Gy) each ablated orthotopic human medulloblastoma in nude mice; FLASH evoked distinct microglial and hippocampal transcriptional programs and less neuroinflammation.

The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.

The paper evaluates antibody design methods using immunogenicity labels and finds that format-based approaches outperform sequence-based predictors, but label inaccuracies limit progress.

This study investigates how metabolic dysfunction and metformin affect plasma extracellular vesicle signaling to prostate cancer cells, identifying specific miRNAs and their effects on tumor progression.

This study uses a folate-targeted nanoprobe to image neuroinflammation in Alzheimer's disease models via molecular MRI, showing enhanced signal in transgenic mice with pro-inflammatory microglia.

This study develops a mouse model of exercise-induced whole body hyperthermia that mimics skeletal muscle injury features observed in heat stress.

This study identifies bZIP transcription factors and inhibitors that influence T-cell proliferation and cytotoxicity under exhaustion conditions.

The paper shows that growth-mediated compressive stresses drive millimeter-scale gap closure in MEC1 cells, with fluid-like tissue remodeling enhancing collective closure.

This study shows that ascorbate and TET2 promote balanced hematopoiesis, which is essential for surviving malaria and reducing disease severity.

This study shows TRPM7 kinase activity modulates pathogenic TH17 cell differentiation and function, with reduced TRPM7 activity leading to milder EAE and increased Tregs in mice.

This paper uses pesticide toxicity data to identify substances that improve survival and healthspan by affecting mitochondrial bioenergetics.

The paper introduces kGain, a metric quantifying k-mer frequency shifts due to mutations, and shows it predicts adaptive potential across species and experimental systems.