Neurotransmitter Receptor Influence on Behavior

This paper introduces a longitudinal opto-fMRI assay to study SSRI effects on the mouse serotonergic system, revealing a brainstem neurophenotype and no persistent effects after treatment cessation.

This study shows that changes in social rank in pigs are associated with changes in cerebrospinal fluid dopamine levels, with upward rank shifts linked to increased dopamine.

This study identifies a common molecular mechanism involving mGluR2 dysfunction linking cognitive deficits and alcohol craving, and develops a biomarker for targeted interventions.

This study identifies sex-specific synaptic changes in the prefrontal cortex that underlie opioid-induced cognitive impairment and suggests sex-based interventions for addiction treatment.

This study identifies distinct sustained neural states in dopaminergic and noradrenergic networks that mediate different aspects of exploitative behavior.

This study investigates the role of Hnrnph1 in fentanyl-induced behaviors, finding reduced sensitivity and reward in mutants with sex-specific effects.

The paper investigates how enhancing pyramidal neuron excitability in the prelimbic cortex affects behavior, finding that such manipulations replicate cocaine-induced behavioral changes.

The paper investigates the interaction between BMI, COMT, DRD2/ANKK1 SNPs, and temporal impulsivity in men, finding that DRD2/ANKK1 SNPs interact with temporal impulsivity to influence BMI.

This study shows that SSRIs alter the balance of learning from rewards and punishments by enhancing punishment learning and reducing reward learning.

Longitudinal fiber photometry in mice shows midbrain dopamine ramping appears immediately in novel spatial navigation, fades as cues become familiar, and persists when an internal distance model is required.

The paper investigates how reward expectations are influenced by internal representations in rodents, finding that efficient, compressed representations best match both behavior and dopaminergic activity.

The paper identifies a cortico-thalamic loop between the medial prefrontal cortex and anteromedial thalamus that regulates motivation, reinforcement, and dopaminergic activity through reciprocal connectivity and feedback.

This study shows dopamine firing encodes reward prediction errors and motivation during a working memory task in monkeys, with distinct roles for phasic and tonic activity.

This study tests suvorexant's ability to reduce fentanyl-related addiction-like behaviors in rats, finding it effective in decreasing motivation and reinstatement without affecting locomotion or natural rewards.

This study shows methylphenidate increases preference for mental labor over leisure, especially in individuals with higher baseline striatal dopamine.

The paper investigates the role of c-Fos and MMP-9 in the central amygdala, finding they mediate approach motivation but not reward consumption.

This study shows that different firing patterns of the locus coeruleus in rats affect learning and valence through distinct neural circuits involving the ventral tegmental area and basolateral amygdala.

This paper conducts a systematic review and meta-analysis of dopamine drug effects on reward discounting in healthy rats, finding DAT-modulating drugs decrease discounting while D1/D2 antagonists increase it.

This study investigates how dopamine affects memory consolidation of music, finding that dopaminergic interventions modulate memory recognition and pleasantness of music in individuals sensitive to musical reward.

This study shows that cilia loss in specific neurons affects locomotor responses to amphetamine differently in males and females.

This study shows that VTA dopamine neurons encode internal effort signals during reward- and escape-motivated jumping tasks.

Sleep deprivation rapidly increases serotonin 2A receptor expression in the mouse frontal cortex through the immediate early gene Egr3.

The paper shows that adolescent social isolation causes sex-specific changes in the medial amygdala's transcriptome and behavior, with Crym playing a key role in these effects.

Cholinergic basal forebrain neurons and cortical acetylcholine release encode an unsigned, valence-free reinforcement prediction error that tracks learning alongside dopamine via shared upstream circuits.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.

This study investigates the role of CeA CRF neurons in alcohol dependence by using chemogenetics to assess their impact on behavior and neurotransmission during withdrawal.

This study investigates the neurochemical basis of hedonic facial reactions to social and nonsocial rewards by manipulating dopaminergic and opioidergic systems in humans.

This study investigates the effects of COMT inhibition on effort-related choice behavior in male mice and finds no significant impact on task performance.

This study shows that cerebellar dopamine D2 receptors in Purkinje cells regulate social novelty preference in mice without affecting motor functions.

This study identifies six novel missense SNPs in the MAOA gene associated with aggressive behavior using bioinformatics analysis.