Smoking Behavior and Cessation

Transitioning to e-cigarettes restores the immune response to house dust mite in cigarette smoked mice.

This study shows that short-term e-cigarette use after cigarette smoke exposure restores immune response to house dust mites, but long-term use may not fully restore immunity.

Vaping and smoking cue reactivity in young adult electronic cigarette users who have never smoked combustible cigarettes: a functional neuroimaging study

This study uses fMRI to show that young adult e-cigarette users who never smoked combustible cigarettes have heightened neural reactivity to both vaping and smoking cues.

AB-free kava enhances resilience against the adverse health effects of tobacco smoke in mice

This study evaluates AB-free kava's effects on tobacco smoke-exposed mice, showing it mitigates health deficits with safety, suggesting potential for reducing tobacco-related harm.

An In-Vitro Standardized Protocol for Preparing Smoke Extract Media from Cigarette, Electronic Cigarette and Waterpipe.

This paper presents a standardized protocol for generating smoke extract media from cigarette, electronic cigarette, and waterpipe smoke to enable consistent in vitro studies of smoke-induced effects.

Cardiac p16 Expression Following Vape Exposure with Nicotine Shows Sex-Specific Induction in Males but not Females

This study shows nicotine in vape aerosol induces p16 expression and collagen deposition in male cardiac tissue but not females, while vape alone increases fibroblasts without collagen changes.

The role of β-Nicotyrine in E-Cigarette abuse liability I: Drug Discrimination

This study examines β-Nicotyrine's effects on nicotine discrimination in rats, finding it prolongs nicotine's stimulus properties but does not fully substitute for nicotine.

Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses

This study investigates the role of NRG3-ERBB4 signaling in the ventral hippocampus during nicotine withdrawal, showing its impact on anxiety-like behaviors and synaptic function.

Intermittent Nicotine Access is as Effective as Continuous Access in Promoting Nicotine Seeking and Taking in Rats

This study shows that intermittent nicotine access in rats produces addiction-like behaviors similar to continuous access, despite lower nicotine intake.

A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers

The paper shows that nicotine-related beliefs in smokers induce dose-like thalamic responses and functional coupling with prefrontal cortex, similar to pharmacological effects.

Decoding of resting-state using task-based multivariate pattern analysis supports the Incentive-Sensitization Theory in nicotine use disorder

This study uses fMRI and multivariate pattern analysis to show that wanting-related brain patterns persist longer in individuals with nicotine use disorder, supporting the Incentive-Sensitization Theory.

Bidirectional relationship between attentional deficits and escalation of nicotine intake

This study shows that pre-existing attentional deficits predict nicotine intake escalation in rats, and withdrawal from nicotine causes attentional deficits that are reversed by acute nicotine.

Withdrawal from repeated nicotine vapor exposure increases somatic signs of physical dependence, anxiety-like behavior, and brain reward thresholds in adult male rats.

This study examines the effects of nicotine vapor withdrawal in rats, finding increased plasma cotinine, somatic signs, anxiety-like behavior, and elevated reward thresholds.

Tobacco Images Choice and Its Association with Craving and Dependence in Cigarette Smokers

This study develops and validates the probabilistic image choice (PIC) task to measure tobacco image seeking behavior in smokers, finding it correlates with craving but not other dependence measures.

Methoxsalen inhibited the acquisition of nicotine self-administration: attenuation by cotinine replacement in rats

The paper investigates how methoxsalen inhibits nicotine self-administration in rats and shows that cotinine replacement can counteract this effect.

Strawberry additive increases nicotine vapor sampling and systemic exposure but does not enhance Pavlovian-based nicotine reward in mice

This study investigates how a strawberry additive affects nicotine reward and exposure in mice, finding increased vapor sampling but no enhancement of reward.

People with a tobacco use disorder misattribute non-drug cues as worse predictors of positive outcomes compared to drug cues

This study shows that people with tobacco use disorder misattribute non-drug cues as weaker predictors of positive outcomes compared to drug cues, supporting some but not all hypotheses of the salience misattribution model.

Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 modulates the motivation to chronically self-administer nicotine

This study inactivates PDE4B in rat nucleus accumbens shell using CRISPR/Cas9 and shows it increases nicotine self-administration motivation despite higher effort requirements.

Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving

Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK

This study identifies genetic variants associated with smoking initiation and cessation in men of African ancestry, highlighting underrepresented populations in genetic research.

Rare coding variants in CHRNB2 reduce the likelihood of smoking

The paper identifies rare coding variants in CHRNB2 associated with reduced smoking likelihood and links them to downstream smoking-related phenotypes.

Pupil size as a robust marker of attentional bias toward nicotine-related stimuli in smokers

This study finds that pupil size changes in response to nicotine-related stimuli can predict smoking status better than traditional measures in young smokers.

Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration

This study investigates the effects of intermittent nicotine self-administration in rats, finding increased nicotine seeking and neurobiological changes compared to continuous access.

Role of anterior insula cortex in context-induced relapse of nicotine-seeking

This study identifies the anterior insula cortex's role in context-induced relapse to nicotine-seeking using a rodent model and chemogenetic inhibition.

Neuroaffective profiles are associated with e-cigarette use

The paper links neuroaffective responses to nicotine-related cues with higher e-cigarette use frequency in smokers.

Not all smokers are alike: The hidden cost of sustained attention during nicotine abstinence

The paper identifies two smoker subgroups based on task performance during a cognitive challenge and shows only one subgroup exhibits attention deficits during nicotine abstinence.

Alcohol and Vapourized Nicotine Co-Exposure During Adolescence Contribute Differentially to Sex-Specific Behavioural Effects in Adulthood

This study examines how adolescent exposure to alcohol and vapourized nicotine affects reward and cognition in adult male and female rats, finding sex-specific behavioural differences.

Smoking-dependent expression alterations in nasal epithelium reveal immune impairment linked to germline variation and lung cancer risk

The paper identifies persistent smoking-related immune alterations in airway tissues and links them to genetic risk factors and lung cancer risk using transcriptomic data and GWAS integration.

Fundamentals of Vaping-Associated Pulmonary Injury Leading to Severe Respiratory Distress

This study demonstrates vaping-induced pulmonary injury in mice using a JUUL pen inhalation model, showing structural and transcriptional changes linked to respiratory distress.

Evidence of individual differences in motives for nicotine seeking in classical nicotine self-administration and associated outcomes of varenicline administration

The paper identifies individual differences in nicotine seeking motives in rats and shows varying responses to varenicline during nicotine withdrawal.

Comprehensive Assessment of Smoking and Sex Related Effects in Publicly Available Gene Expression Data

The paper analyzes smoking and sex effects on gene expression across multiple tissues using public data, identifying tissue-specific and sex-related gene expression changes.