MicroRNA in disease regulation

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

The paper introduces Scan, a framework that infers sample-specific miRNA regulation from bulk and single-cell RNA-sequencing data using multiple network inference methods.

This study examines longitudinal associations between circulating microRNAs and weight changes over two years in the Diabetes Prevention Program.

The paper introduces Mimosa, a Transformer-based model for miRNA target prediction that incorporates non-canonical base-pairing patterns, achieving better performance than traditional methods.

This study identifies miR-100 and miR-125b as regulators of 3D growth and invasiveness in cancer cells, showing they can be transferred extracellularly to silence target genes in recipient cells.

Gra-CRC-miRTar is a pre-trained graph neural network framework for identifying miRNA targets in colorectal cancer, achieving better performance than existing methods and revealing functional interactions.

The paper identifies miR-4787-3p as an essential miRNA for breast tumor-initiating cell growth using CRISPR screens and validates its role as a potential therapeutic target and prognostic biomarker.

PRIMITI predicts miRNA-target mRNA interactions using machine learning with CLIP-seq and expression data, achieving high AUC scores and outperforming existing methods.

This study identifies miR-6741-3p as a tumor suppressor in oral squamous cell carcinoma by targeting SRSF3, showing its potential as a therapeutic target.

This study identifies miR-497 as a tumor suppressor in angiosarcoma by regulating target genes like CCND2, CDK6, and VAT1, with VAT1 inhibition reducing tumor migration.

This study identifies miR-144 and Hmgn2 as key regulators of chromatin condensation during erythropoiesis, showing their conserved role from fish to humans.

The paper introduces mime-seq 2.0, a method to sequence microRNAs from specific mouse cell types using a chimeric RNA methyltransferase tethered to Argonaute.

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

This study identifies DNJ-12 as a co-chaperone specific to ALG-1, a miRNA-specific Argonaute in C. elegans, showing its role in miRNA function and gene silencing.

The paper introduces MoPc, a tool that predicts miRNA-target interactions by analyzing multi-omic data, and validates its results on cancer datasets.

This study identifies non-canonical Drosha substrates in mouse ESCs, showing they differ from miRNA stem-loops in processing efficiency, stability, and cleavage features.

The paper identifies RNA-RNA interactions between RSV and miR-26/miR-27, showing their roles in cell cycle and antiviral immunity through target gene networks and nuclear localization.

This study evaluates folate-conjugated miR-34a as a potential prostate cancer therapeutic, finding limited efficacy due to low FOLR1 expression in prostate cancer cells.

This paper identifies sex-specific miRNA expression differences in Alzheimer's disease patients through meta-analysis of blood and brain samples, revealing distinct biological process associations in each sex.

This study identifies RPL24 as a regulator of miR processing and tRF production, showing its interaction with DDX5 and its effect on miR levels and tRF profiles in human and plant cells.

The paper identifies four kinases whose knockdown causes vulval defects in alg-1(0) C. elegans mutants after dauer, suggesting they regulate miRISC activity during post-dauer development.

This study identifies miR-644a as a tumor cell-intrinsic mediator of sex bias in glioblastoma, showing it is more highly expressed in females and its target genes are linked to poorer survival.

The paper shows that microRNA activity is essential for early mouse embryos to transition into diapause, with miRNAs regulating gene expression and linking mTOR activity to miRNA biogenesis.

The paper identifies miR-182-5p as a key microRNA linking type 2 diabetes and fatty liver disease through its regulation of LRP6 in human and mouse liver samples.

This study shows that oxidative stress modifies miR-483 to 8OH-G miR-483, leading to endothelial dysfunction and increased atherosclerosis risk through altered targetomes.

This study shows that miR-138-5p upregulation during neuronal maturation reduces apoptosis and increases neuronal survival by modulating Caspase3 expression and activity.

Rocket-miR predicts human miRNA interactions with pathogens to identify potential antimicrobial candidates against antibiotic-resistant infections.

The paper identifies a miRNA phenotypic target through de novo analysis in a medaka model, revealing miR-202 regulation of egg production via the Hippo pathway.

The paper identifies post-transcriptional regulators in early human small intestinal development using multi-omic analyses and presents a web tool for exploring miRNA regulation.