Nanoparticle-Based Drug Delivery

In vitro efficacy and in vivo toxicity and retention of targeted nanoformulated carboplatin in a sustained release carrier for treatment of osteosarcoma

Nanocarrier Drug Release and Blood-Brain Barrier Penetration at Post-Stroke Microthrombi Monitored by Real-Time Förster Resonance Energy Transfer-Based Detection System (FedEcs)

This paper develops a real-time FRET-based system to monitor nanocarrier behavior and drug release at post-stroke microthrombi in vivo.

A Straightforward Approach for Living Biomembrane Printing onto Nanoparticle

This paper describes a method to coat living cell membranes onto nanoparticles, demonstrating improved biocompatibility and reduced phagocytosis.

Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice.

This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.

Cell-specific cargo delivery using synthetic bacterial spores

This study demonstrates that SSHELs, synthetic bacterial spore-like particles, can deliver chemotherapy to HER2-positive cancer cells with reduced toxicity and effectiveness in tumor models.

Spatial Transcriptomics-based Identification of Molecular Markers for Nanomedicine Distribution in Tumor Tissue

The paper identifies molecular markers associated with nanomedicine distribution in tumor tissue using spatial transcriptomics and fluorescence imaging.

Generic Purpose Pharmacokinetics-Pharmacodynamics Mathematical Model For Nanomedicine Targeted Drug Delivery: Mouse Model

The paper presents a spatio-temporal PKPD model for nanoparticle-based drugs, showing improved fidelity over existing models in mouse experiments with 13 NPs.

Graph-Based Pharmacokinetic-Pharmadynamic Modeling for Large Scale Systems: Nanoparticles Case

This study introduces a graph-based PKPD model for nanoparticles to predict treatment outcomes, achieving high fitting accuracy in in vivo experiments.

Multifunctional phosphate based nanoparticles as a platform for imaging, targeting and doxorubicin delivery to human breast cancer CD44+ cells.

This paper develops multifunctional phosphate-based nanoparticles for imaging and targeted doxorubicin delivery to breast cancer cells, showing reduced cytotoxicity and effective drug delivery.

Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers

The paper demonstrates that dye-functionalized lipid nanocarriers can deliver a PI3Kγ inhibitor to hepatocytes, restoring liver function in sepsis without affecting immune responses.

Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles forcholesterol delivery in Huntington disease

This study evaluates hybrid nanoparticles for delivering cholesterol to the brain in Huntington disease, showing improved targeting, controlled release, and therapeutic benefits without inflammation.

Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity

This paper develops a nanoparticle formulation of vismodegib that improves its efficacy for medulloblastoma treatment by enhancing CNS pharmacokinetics and reducing systemic toxicity.

Decreased viability and neurite length in neural cells treated with chitosan-dextran sulfate nanocomplexes

This study evaluates the neurotoxic effects of chitosan-dextran sulfate nanocomplexes on neural cells in vitro and finds reduced viability and neurite length.