Nanoparticle-Based Drug Delivery

Tunneling Effect with Time-Dependent Effective Potential Barrier: A Semiclassical (WKB) Reinterpretation of Drug Release Kinetics in Polymeric Nanocapsules

The paper reinterprets drug release kinetics in polymeric nanocapsules using a time-dependent effective potential barrier model, showing improved fit over WKB approximations and distinguishing between decay models.

Nab-paclitaxel fused with the de novo designed receptor binder exhibits enhanced tumor targeting and therapeutic efficacy

This paper modifies Nab-paclitaxel with receptor binders to improve tumor targeting and reduce toxicity, showing enhanced efficacy in cancer cells and xenograft models.

Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation

This study shows that the outer polyion layer of layer-by-layer nanoparticles affects protein corona formation, which influences their biodistribution and therapeutic efficacy.

Magnetic particle imaging reveals heterogeneous retention, leakage and redistribution of nanoparticles following intratumoral injection

This study uses magnetic particle imaging to track nanoparticle distribution and fate after intratumoral injection, revealing heterogeneous retention, leakage, and systemic redistribution.

Lung-Selective Immune Reprogramming via In Situ Red Blood Cell Hitchhiking Nanoparticles

This paper introduces i-Bind, a nanoparticle strategy that hitchhikes on red blood cells in situ to enhance lung targeting and immune reprogramming in mice.

A permeable protein nanocage enables facile cargo loading and cytosolic protein delivery

This paper introduces a permeable protein nanocage, QtEnc, enabling rapid and efficient cytosolic protein delivery through post-assembly cargo loading and pH-triggered release.

Integrin Activation Enhances Lesion-Specific Targeting of Monocyte-Mimetic Nanoparticles in Atherosclerosis

This study shows that activating integrins on monocyte-mimetic nanoparticles improves their targeting to atherosclerotic lesions without increasing toxicity.

Lipid nanoparticle protein coronas arise through lipoprotein fusion rather than shell-like adsorption

This study shows lipid nanoparticles form protein coronas through lipoprotein fusion, not surface adsorption, using cryo-EM and simulations.

Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis

This study develops glomerulus-targeted nanotherapy using collagen IV-α3 binding peptides to improve renal function and reduce inflammation in lupus nephritis.

A Partition-Controlled Kinetic Model for Drug Release from Polymeric Nanocapsules: Resolving the Solubility Paradox

This paper develops a kinetic model for drug release from polymeric nanocapsules that resolves the solubility paradox by showing the effective release rate is inversely proportional to drug solubility.

Mesenchymal Stem Cell Membrane Coating of Gelatin Nanospheres with Drug Release Ability for Inflammatory Tissue Targeting

This paper develops MSC-coated gelatin nanospheres for targeted drug delivery to inflammatory tissues, showing enhanced retention and therapeutic effect in liver fibrosis.

Enhanced Zika Virus Suppression by Coupling Ribavirin with Biodegradable Drug Delivery

This paper develops pH-responsive biodegradable micellar nanoparticles for ribavirin delivery against Zika virus, showing enhanced antiviral efficacy and reduced cytotoxicity.

Modular in vitro evaluation of Buparlisib-polymeric nanomedicines in 2D and 3D models of glioblastoma

This study evaluates Buparlisib-polymeric nanomedicines in 2D and 3D glioblastoma models, finding that redox-sensitive conjugates show better activity than azide-based ones.

Hydroxy polyethylene glycol: a solution to evade human pre-existing anti-PEG antibodies for efficient delivery

This study shows that hydroxy PEG (OH-PEG) reduces binding to pre-existing anti-PEG antibodies, improving stability and reducing immunogenicity of PEGylated nanomedicines.

The delivery of nano-formulated drugs to solid tumours is selectively increased by co-application of the vascular disrupting agent CA4P

This paper shows that co-administering vascular disrupting agents with nanoparticle drugs increases tumoral uptake without increasing systemic exposure.

Precision control of nanoparticle delivery with engineered biomimetic protein coronas

This paper engineers biomimetic protein coronas on nanoparticles to improve tumor targeting and reduce immune recognition, achieving 4% ID/g tumor accumulation.

Process for Standardizing and Assessing the Parameters Governing MS2 Virus-Like Particle Reassembly around Nucleic Acid Cargo

This paper introduces a standardized framework to quantify MS2 VLP reassembly yields and identifies key parameters affecting reassembly efficiency.

Detailed splenic single-cell biodistribution of phosphatidylglycerol-containing liposomes

This study compares the biodistribution of rigid and flexible liposomes in the spleen and identifies APC subsets involved in immune tolerance.

A modular method for rapidly prototyping targeted gas vesicle protein nanoparticles

The paper describes a modular method to create targeted gas vesicle protein nanoparticles using His-tagged antibody fragments and Ni-NTA functionalization, validated for PSMA targeting.

Modeling lipid nanoparticle transport in extracellular matrix: Effects of particle size and rigidity

This study models lipid nanoparticle transport through extracellular matrix, showing how particle size and rigidity affect diffusion and highlighting the importance of particle-to-matrix size ratio.

Hyaluronic acid-b-polylactic acid polymersomes facilitate CD44-mediated delivery of doxorubicin to glioblastoma in vitro

This study develops HA-PLA polymersomes to deliver doxorubicin to glioblastoma cells, showing CD44-mediated uptake and apoptosis induction.

Escape from Cell Uptake: Drug-Free Cancer Therapeutics Regulated Hydrophobicity and Negative Charge

This study investigates how varying grafting degrees of PVA-U affect its cytotoxicity in response to tumor microenvironment stimuli, showing that PVA-U15 exhibits the highest selectivity due to its aggregation and cell membrane adsorption properties.

Surface avidity of anionic polypeptide coatings target nanoparticles to cancer-associated amino acid transporters

The paper shows that anionic polypeptide coatings on nanoparticles bind to cancer-associated amino acid transporters, enabling targeted drug delivery through electrostatic interactions and transporter clustering.

Polymer functionalized liposomes as universal nanocarriers for drug delivery: Single particle insights on size-dependent performance and intracellular behavior

This study develops polymer-modified liposomes (PMLs) for drug delivery, showing size-dependent cargo packing and effective intracellular delivery of various cargoes including siRNA.

Stainless Steel-Synthesized Gold Nanoparticles: Insights into Blood-Brain Barrier Permeability and Microglial Interaction.

This study evaluates stainless steel-synthesized gold nanoparticles' ability to cross the blood-brain barrier and interact with microglia, showing dose-dependent cytotoxicity and minimal inflammation.

PEGylation strategies for enhanced nanoparticle delivery to tumor associated immune cells

This study evaluates how linear and branched PEGylation affects nanoparticle uptake and distribution in tumor and immune cells, showing branched PEG increases spleen accumulation and linear PEG enhances tumor uptake by immune cells.

Semisynthetic Ferritin Nanocages for Flexible, Site-specific Targeting, Cluster-formation and Activation of Membrane Receptors

This paper introduces a semisynthetic ferritin-based nanoparticle that specifically targets and clusters membrane receptors, inducing apoptosis via CD95 clustering.

Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics

This study investigates how spike structures on virus-like nanoparticles enhance immune responses in macrophages through proteomic analysis of signaling pathways.

Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking

This study shows that ionic liquid-coated lipid nanoparticles can hitchhike on red blood cells, improving brain uptake and circulation time compared to uncoated nanoparticles.

'Target-and-release' nanoparticles for effective immunotherapy of metastatic ovarian cancer

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.