Parkinson's Disease Mechanisms and Treatments

The paper constructs tissue-specific LRRK2 interactomes and identifies a functional cluster within the striatum, highlighting distinct expression patterns and interactions in brain regions.

This study identifies penetratin as an inhibitor of α-synuclein aggregation and shows it improves locomotor function in Parkinson's disease mouse models.

The paper investigates SLC25A46 variants in Parkinson's disease using whole-genome sequencing data and finds no significant association with PD in European ancestry populations.

This study shows human pericytes degrade different strains of alpha-synuclein aggregates in vitro, with varying efficiency depending on the strain and origin of the pericytes.

The paper identifies specific structural features of flavones that confer neuroprotection against paraquat-induced Parkinson's disease in Drosophila.

This study identifies prodromal Parkinson's disease features in adults with 22q11.2 microdeletion syndrome, showing signs like hyposmia and dysautonomia, with some evidence of dopaminergic signaling changes.

The paper investigates cortical oscillatory activity in atypical parkinsonian syndromes and finds that slowing of frontocentral beta oscillations distinguishes these syndromes from healthy controls and idiopathic Parkinson's disease.

The paper investigates sensory system aberrations in a Parkinson's Disease mouse model using fMRI and finds neural origins for observed deficits.

This study identifies DX2, an AIMP2 splice variant that inhibits PARP-1 and alleviates Parkinson's disease symptoms in animal models.

This study tests whether selective modulation of muscarinic receptors M1, M4, or M5 can reduce parkinsonian tremor, finding no effect and suggesting M2 or M3 receptors may be responsible for anti-tremor efficacy.

The paper introduces DeePhys, a tool for functional phenotyping of neurons using electrophysiological data, and shows it can predict genotype and age in iPSC-derived DA neurons with the A53T SNCA mutation.

The paper shows that neighboring post-translational modifications affect the detection of phosphorylated alpha-synuclein at Serine 129 by existing antibodies.

This study identifies a homozygous CADPS2 mutation in parrots causing neurodegenerative disease with Lewy bodies and reduced proteasome activity.

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

This study identifies pathogenic variants in dystonia-parkinsonism genes in 12.5% of SWEDD cases in the PPMI cohort, highlighting the importance of genetic testing in this patient group.

This study shows that dietary fibre deprivation and bacterial curli exposure worsen PD-like symptoms in mice overexpressing human alpha-synuclein.

The paper uses machine learning to classify Parkinson's disease patient-derived midbrain dopaminergic neurons based on multiple image-based phenotypes and identifies treatable targets.

This study investigates the link between Parkinson's disease and diabetes mellitus using Drosophila models, finding that T2DM may increase PD risk and that metformin could prevent PD onset in T2DM models.

This study identifies cell-type-specific dysregulated cis-regulatory elements and target genes in Parkinson's disease using multi-omic analyses of single-cell transcriptomes and epigenomes.

The paper measures how different cellular environments affect alpha-synuclein's structure and aggregation, finding that specific regions drive nucleation and fibril elongation.

The paper was withdrawn due to lack of full author consent, so no findings are reported.

The paper identifies mtDNA damage as a blood-based biomarker for Parkinson's disease, showing increased levels in early-stage patients and mutation carriers, suggesting its potential for patient stratification in clinical trials.

This study shows that inflammatory bowel disease (IBD) leads to α-synuclein aggregation in the gut and brain, supporting Braak's hypothesis of Parkinson's disease origin in the enteric nervous system.

The paper shows that inducing LTD in corticostriatal inputs to indirect pathway neurons in a Parkinsonian mouse model leads to prolonged relief of motor symptoms.

This study investigates how glycation of alpha-synuclein affects its oligomerization and microglia activation, showing conformation-specific neuroinflammatory effects.

This study identifies a striatal plasticity mechanism that delays motor deficits in a Parkinsonian mouse model by preserving direct pathway connectivity through transient dopamine neuron activity elevation.

The paper compares midbrain neurons from PD patients with mutations and sporadic PD, finding reduced synaptic activity and dysregulated extracellular matrix pathways as common features.

This study investigates how the size of α-synuclein fibril seeds affects their amplification, cellular uptake, and toxicity, revealing distinct mechanisms for small and large seeds.

The paper identifies methylxanthine as a potential inhibitor of SNCA protein through computational analysis, suggesting its therapeutic potential for Parkinson's disease prevention.

The paper investigates the effects of the E83Q mutation on alpha-synuclein aggregation and toxicity, finding it accelerates fibrillization and enhances pathological features in neuronal models.