HIV Research and Treatment

This paper develops an evolutionary model incorporating migration and recombination to explain varying HIV-1 compartmentalization signals across tissues.

This study identifies Dll4 as a novel contributor to persistent systemic inflammation in HIV patients through monocyte-derived Notch1 activation.

The paper profiles RNA in brain tissue and derived extracellular vesicles from SIV-infected macaques to identify dysregulated RNAs and their potential roles in CNS pathology.

This study models HIV dynamics in lymph node sanctuary sites under antiretroviral therapy and finds that ongoing replication contributes very slowly to the total latent HIV pool.

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

This study identifies genetic variants influencing CCR5 expression on immune cells in HIV-positive and healthy individuals, showing cell-specific regulation and effects on inflammatory mediators.

This study analyzes HIV-1 genetic diversity in Sub-Saharan African countries using whole-genome sequences to identify subtype-specific polymorphisms and cross-border genetic exchange.

The paper uses single-cell DNA sequencing to show that defective HIV genomes contribute to phylogenetic inference of reservoir dynamics in an animal model.

This study profiles HIV-1 integration sites in microglia and links viral insertions to topologically associated domain organization.

This study shows that cocaine worsens HAND symptoms in an HIV mouse model by altering DNA methylation and gene expression, affecting neuronal and glial functions.

The paper investigates host genetic variations in MX1, CCR5Δ32, and MHC class I alleles in HIV+ non-controllers on ART and finds associations with HIV reservoir size.

The paper investigates how HIV-1's RNP granules regulate protease activity through phase separation, revealing key RNA-binding motifs and their role in viral maturation.

The paper describes the engineering of HIV-1 Env variants enriched in a pretriggered conformation, which are more stable and crosslinkable, aiding in structural and immunogenic studies.

This study examines HIV-1 associated apathy in rats by analyzing goal-directed behaviors and synaptic dysfunction in the nucleus accumbens.

The paper presents two models explaining the difference in HIV reservoir turnover rates with and without antiretroviral therapy and explores strategies for reservoir reduction.

This paper introduces a novel humanized mouse model resistant to GVHD that supports HIV-1 infection and is valuable for preclinical HIV research.

The paper identifies 25 anti-HIV genes and their regulatory networks using transcriptome, epigenome, and proteome data from HIV-resistant individuals.

The paper identifies an IL-15 response signature in vaccinated rhesus macaques that correlates with protection against SIV challenge following RhCMV/SIV vaccination.

This study evaluates the effects of S-equol on apathy and drug-seeking behavior in HIV-1 transgenic rats, finding it mitigates these issues.

This study identifies rare genetic variants associated with HIV-1 progression in a Botswana population using whole genome sequencing and statistical analysis.

This paper introduces a Bayesian method to estimate HIV infection timing from unmutated sequences, avoiding data curation and providing accurate results robust to complications like APOBEC hypermutation.

This study investigates cognitive dysfunction in older HIV+ men using EEG and MRI, finding that attention-related neural circuits are more affected than inhibitory control circuits.

This study investigates HIV-1 persistence in the brain using HIV-1 transgenic rats and a novel EcoHIV model, showing microglia as the primary cell type expressing HIV-1 mRNA and linking infection to neurocognitive impairments.

This study shows HIV-1 gp120 impairs spatial memory by inhibiting CREB activity, leading to mitochondrial dysfunction and synaptic plasticity loss.

This paper introduces a microfluidic method to sequence HIV proviruses and their integration sites, achieving >90% capture and sequencing of paired genomes from treated patients.

The paper identifies a conserved but genetically flexible motif in HIV-1 integrase's C-terminal domain that is essential for integration and other functions.

The paper uses integrated genomics data to identify chromatin states and nuclear compartments influencing HIV-1 proviral transcription and fate.

This paper describes a high-throughput method for cloning HIV-1 env genes using Phusion polymerase and overlap extension PCR, enabling efficient analysis of diverse env genes from infected individuals.

The paper develops a mathematical model to uncover the nonequilibrium mechanism behind drug synergy between Activators and Noise Enhancers in HIV latency reactivation.

This paper discovers and engineers an HIV-1 Therapeutic Interfering Particle (TIP) that suppresses viral replication and protects CD4+ T cells in humanized mice.