Antibiotic Resistance in Bacteria

This study characterizes two multidrug-resistant E. coli strains from bovine mastitis in Bangladesh, revealing their resistome, virulome, and evolutionary relationships.

This study evaluates screening methods to detect ESBL-producing E. coli and K. pneumoniae in healthcare environmental samples, finding that 18-hour pre-enrichment and specific selective agar improve detection.

This study shows how mobile genetic elements synergistically drive the stepwise accumulation of antibiotic resistance genes in plasmids, proposing a framework to predict and surveil multidrug resistance.

The paper shows that a shift in pre-existing antibiotic heteroresistance, not de novo mutation, explains a change from susceptible to resistant classification during treatment.

This study shows that a single conserved residue transfer between RND efflux pump clusters alters drug resistance and conformational dynamics.

This study characterizes a multidrug-resistant Proteus mirabilis isolate from India, revealing AMR genes, virulence factors, and novel genomic features associated with its pathogenic potential.

This study shows that the gyrBD429N mutation in Neisseria gonorrhoeae confers cross-resistance to gepotidacin and has variable fitness effects across strains.

amr.watch provides an interactive platform to analyze and visualize AMR trends from global WGS data, enabling ongoing situational awareness for research and policy.

This study identifies MSMEG_6194 in Mycobacterium smegmatis as a DD-carboxypeptidase, showing that a single amino acid substitution converts its activity to beta-lactamase.

The paper identifies a large number of potential beta-lactamases across diverse bacterial genera and highlights the role of horizontal gene transfer in spreading antibiotic resistance.

This study identifies mutHV76G in K. pneumoniae causing hypermutation, antibiotic resistance, and plasmid acquisition without fitness cost.

The paper identifies a new PAC-2 β-lactamase variant in a K. quasipneumoniae isolate from Colombia conferring resistance to ceftazidime-avibactam.

The paper analyzes K. pneumoniae genomes to show convergence between antimicrobial resistance and hypervirulence, identifying dual-risk clones and geographic hotspots.

This study identifies key mutations in PBP2 from a ceftriaxone-resistant Neisseria gonorrhoeae strain that balance resistance and transpeptidase activity.

The paper integrates metagenome-assembled genomes with clinical isolates to identify genomic signatures of K. pneumoniae in carriage and disease, revealing distinct diversity and improved classification using machine learning.

This paper develops wzi-Seq, a method to detect and quantify Klebsiella strains in gut samples, and finds that mono-colonization is associated with increased infection risk.

This study investigates how ecological interactions influence the growth of antibiotic-resistant E. coli strains in human gut microbiomes, finding that strain-specific factors and competitive interactions drive their success.

The paper introduces a pipeline using PPINs and machine learning to identify ARGs, showing improved discrimination of ARGs from nonARGs and their association with mobile genetic elements.

This study investigates how carbamylation of lysine and chloride ions affect OXA-143 dynamics and catalytic efficiency using HDX and MD simulations.

This study assesses antimicrobial resistance in little stints and their aquatic ecosystems in Kenya, finding widespread resistance despite no significant differences between high and low impact sites.

This paper shows that disrupting undecaprenyl phosphate recycling via DedA4 deletion reduces AmpC beta-lactamase production and beta-lactam resistance in P. aeruginosa.

This study analyzes KPC-NDM-CRKP isolates to show how mutations, horizontal transfer, and accessory genome plasticity contribute to their epidemiological success.

This study compares the proteomic responses of imipenem-resistant and wildtype Pseudomonas aeruginosa strains, revealing stable resistance mechanisms in the clinical strain and reactive responses in the control strain.

The paper identifies nitrofurantoin-resistant and pre-resistant E. coli clones in poultry and humans across multiple countries, linking them to historical antibiotic use in poultry farming.

The paper quantifies the inoculum effect in β-lactamase-expressing bacteria and shows it is governed by a biphasic trade-off between metabolism and growth rate.

This study maps how β-lactamase mutations confer resistance to different antibiotics, identifying generalist and specialist mutations with distinct mechanisms and positions.

The paper tracks a multidrug-resistant E. coli lineage over years, identifies a globally distributed resistance island, and finds resistance gene co-occurrence networks and antibiotic tolerance in isolates lacking known resistance mechanisms.

This study reports two multidrug-resistant Phytobacter isolates from human colonization, highlighting their plasmid-borne carbapenemase and antimicrobial resistance profiles.

This study investigates the role of MurM and branched cell wall structures in penicillin resistance in Streptococcus pneumoniae, finding no direct correlation between increased branching and resistance.