Hepatitis C virus research

This paper develops a mathematical model integrating HCV infection dynamics with lipid metabolism to show lipid feedback drives viral persistence and oscillations.

This study shows that HCV NS5A does not inhibit the PKR-eIF2 pathway, contradicting previous claims and supporting that HCV replicates despite active PKR response.

This paper develops a consensus HCV E1E2 antigen that engages germline B cell precursors of broadly neutralizing antibodies.

This study shows that HCV reduces Nrf1 proteoforms and inhibits their nuclear translocation, leading to increased cholesterol and lipid droplets, which support HCV replication and pathogenesis.

This study shows that natural variation in HCV IRES affects translation efficiency through epistasis and population-level effects, challenging reliance on dominant sequences.

This paper develops a nanoparticle vaccine platform incorporating native HCV E1E2 to enhance immunogenicity, showing improved neutralizing antibody responses compared to subunit vaccines.

This study identifies lupeol from tamarind as a potent inhibitor of HCV entry by disrupting the E2-CD81 interaction, validated through experimental and computational methods.

This study identifies HCV genotype 4d as predominant among Ethiopian blood donors with no major sofosbuvir resistance-associated substitutions detected.

This paper designs a CD81-binding mini-protein using deep learning to block HCV entry, showing high affinity, stability, and antiviral activity.

This paper develops an agent-based model to simulate HCV cell-to-cell spread in vitro, incorporating cell proliferation, size changes, and foci merging, and shows it fits experimental data well.

This study identifies structural features of HCV E2 glycoprotein recognized by germline B cell receptors and evaluates strategies to enhance germline antibody interactions.

This study shows that thapsigargin inhibits HCV infection by modulating lipid metabolism, affecting both RNA replication and viral egress through distinct mechanisms.

This study examines how HCV replication fitness affects antiviral treatment outcomes, finding that high replication fitness can compensate for resistance mutations and contribute to DAA treatment failure.

The paper isolates E1-dependent broadly neutralizing antibodies against HCV and uses mAbClust with AlphaFold 3 to map a quaternary epitope spanning E1 and E2.

This paper develops a Norway rat hepacivirus reporter system with a HiBiT tag for high-throughput quantification of neutralising antibodies and antiviral responses.

This study shows that B cells in hepatitis C patients retain dysregulated transcriptional profiles after cure, with sustained TNF signaling driving chronic inflammation and loss of protective memory.

HCVTyper is a Nextflow pipeline for HCV genome analysis that enables assembly, genotyping, and resistance detection with reproducible workflows and containerization.

This study identifies genetic risk factors and host-viral interactions for cirrhosis progression in hepatitis C virus-infected patients but finds no genome-wide significant associations for hepatocellular carcinoma.

This study shows membrane binding promotes oligomerization and functional activation of HCV NS5B RdRp by inducing a conformational shift that enhances RNA binding.

This study examines interactions of HCV UTRs with miRNAs, phytochemicals, and proteins, revealing structural changes and novel interactors that may influence viral pathogenesis and antiviral strategies.

The paper identifies repurposing drugs targeting host genes for HCV infection and related HCC by analyzing transcriptomic data from human liver tissues.

This study investigates how phosphatidylinositol phospholipids modulate HCV core protein assembly on lipid membranes, showing that PI(4)P enhances HCC multimerization and capsid formation.

The paper analyzes polymorphisms and conservatism in the HCV NS5B protein, finding solvent accessibility predicts polymorphism and purifying selection drives both polymorphism and conservatism.

The paper develops a multiplex probe panel strategy to improve clinical sensitivity for detecting mutating viruses, achieving 89% sensitivity for hepatitis C virus.

The paper identifies the RdRp Thumb-1 pocket as a conserved target for broad-spectrum antivirals, validated through structural and biochemical analyses of multiple viruses.

The paper determines the structure of HCV E1/E2 envelope proteins in a homodimeric complex using cryo-electron microscopy, revealing details about the dimer interface and antigenic sites relevant to vaccine design.

The paper quantifies the half-lives of HCV NS3 and NS5A proteins under proteolysis system modulators and shows their polyubiquitination and co-localization with autolysosome and proteasome components.

This study identifies PCBP2's role in limiting HCV virion assembly and shows that an alternative RNA conformation facilitates assembly independently of PCBP2.

The paper reports the X-ray structure of HCV genotype 4a NS5b, an RNA-dependent RNA-polymerase, to aid in structure-based drug design.