Influenza Virus Research Studies

This study assesses the seroprevalence of influenza A and B viruses in goats and sheep, finding high antibody rates against avian H5, H7, and H9 subtypes, suggesting these animals may be novel hosts for pandemic influenza viruses.

This study shows that pre-existing antibodies inhibit de novo B cell responses to influenza antigens in mice, but not to other vaccine antigens.

This paper develops a single-component self-assembling nanoparticle vaccine targeting conserved M2e domains from both influenza A and B viruses, showing 100% protection against H1N1 and 70% against Yamagata lineage influenza B in mice.

This study compares macrophage and monocyte responses in young and adult mice during influenza infection, finding divergent mechanisms of lung pathology.

The paper identifies a new influenza A subtype H18N12 in bats from Colombia, based on genetic analysis of viral sequences and phylogenetic studies.

This study identifies the expression of avian and human influenza A virus receptors in bovine mammary glands, suggesting cattle could act as a mixing vessel for novel IAV generation.

This study identifies enhanced diversifying selection on polymerase genes in H5N1 clade 2.3.4.4b viruses, linking it to expanded host range and increased pathogenicity.

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

The paper models within-herd transmission of H5N1 in dairy cattle, estimates R0 near 1.2, and develops a web tool for outbreak simulation and control strategy analysis.

The paper estimates the timeline and parameters of an influenza A(H1N2)v spillover event using likelihood-free rejection sampling with limited data.

This study shows that clade 2.3.4.4b H5N1 influenza viruses bind efficiently to avian-type sialic acid receptors but not human-type receptors.

This study analyzes the evolution of the human influenza A NS gene using temporal distance measures, revealing a continuous genetic backbone and a deviation in the 2009 pandemic.

The paper detects fucosylated and non-fucosylated alpha2,3 sialosides as receptors for HPAIVs in bovine mammary glands using recombinant hemagglutinins.

This paper models the innate immune responses of chickens and ducks to HPAIV, identifying RIG-I as a key molecular difference affecting immune outcomes.

This study identifies RBM3 as a host factor that stabilizes influenza A virus mRNA at cooler temperatures, enhancing viral replication in the upper respiratory tract.

This study reports the spillover of HPAI H5N1 virus to dairy cattle, showing efficient intra- and interspecies transmission and viral tropism in mammary gland epithelial cells.

The paper identifies a new genotype of HPAI H5N1 virus in dairy cattle, showing genetic changes but lacking key mutations for mammalian adaptation.

The paper identifies permissive secondary mutations in A(H1N1)pdm09 influenza virus neuraminidases that increase antiviral resistance and highlights their increasing prevalence over time.

This study identifies Genipin and its derivatives as inhibitors of influenza A virus replication by activating the AMPK-SIRT1-PGC-1α signaling pathway and altering metabolic reprogramming.

This study evaluates the increased pathogenicity and zoonotic potential of an H7N9 LPAIV variant in turkeys, showing enhanced virulence and transmission risks.

This study evaluates HA functionality of UK H5N1 avian influenza viruses from 2020-2022, finding they retain strong avian phenotype with low zoonotic threat.

A unique HPAIV H5N3 genotype caused mass mortality in red knots in 2020, suggesting red knots may act as a reservoir for the virus.

This study uses milk samples from Michigan markets to detect H5N1 avian influenza virus, finding two positive samples suggesting potential HPAI spread in dairy herds.

This study identifies host metabolites, signaling molecules, and cyanobacteria extracts that alter Influenza A defective viral genome production using long-read sequencing.

This study measures viral burst sizes in thousands of infected cells using dqPCR, finding significant variation in H3N2 and H1N1 strains with a small fraction of cells producing most viruses.

This study evaluates COBRA vaccines formulated with cGAMP microparticles in mice, showing enhanced antibody responses and protection against influenza viruses.

This study reports an unusual mortality event in captive bush dogs caused by avian-origin H5N1 influenza A virus.

This paper identifies molecular factors driving the emergence of highly pathogenic H5N1 influenza viruses by showing HA glycosylation and NA stalk length determine subtype pairing and viral fitness.