Pain Mechanisms and Treatments

This study shows that deleting the TRESK K+ channel enhances mechanical and cold sensitivity in mice, indicating its role in regulating neuronal excitability for specific sensory functions.

The paper shows IPSE reduces TRPV1-induced bladder pain in mice through a nuclear localization sequence-dependent mechanism, but not via IL-4.

This study shows that loss of GABAergic neurons in the spinal dorsal horn of a chicken model of spina bifida leads to pain-like behaviors and disrupted sensorimotor networks.

This study investigates acid and inflammatory sensitivity of colonic afferent nerves in naked mole-rats compared to mice, showing differential responses to acid and bradykinin.

This study shows galanin inhibits colonic afferent responses to mechanical and inflammatory stimuli via GalR1, with effects absent in inflamed tissue.

This study shows that GDNF signaling in muscle afferents enhances both nociception and cardiovascular reflexes following ischemic injury.

This study examines gene expression changes in nociceptors distal to spinal cord injury before chronic pain onset, identifying molecular pathways linked to synaptic plasticity and inflammation.

The paper shows excitatory neurons in the spinal dorsal horn are more disinhibited than inhibitory neurons due to chloride dysregulation, despite similar chloride levels, because they rely more on inhibition to balance strong excitation.

This study identifies calretinin-positive neurons in the spinal cord dorsal horn as part of an excitatory network that amplifies pain signals and is a potential target for analgesic therapies.

This paper identifies the P2Y1 receptor's role in regulating non-synaptic cross-depolarization in rat dorsal root ganglia, showing cell-type specific effects and differences in calcium dependence between ganglia.

The paper finds that pain at the ankle biopsy site in HIV-SN patients is associated with lower intra-epidermal nerve fiber density at the ankle compared to the thigh.

This study shows IL-17 from glia suppresses inhibitory synaptic transmission and drives neuropathic pain after chemotherapy.

This study identifies PAG neuronal populations that modulate acute and chronic itch by differentially regulating sensory and affective components through GABAergic and glutamatergic activity.

This study shows TIMP-1 reduces inflammatory pain through both MMP-dependent and receptor-mediated signaling mechanisms.

This study evaluates the pharmacokinetics and analgesic effects of fenobam, an mGlu5 antagonist, in healthy humans, finding variable plasma exposure and minimal analgesic effects at tested doses.

The paper shows that conditioned medium from painful schwannomatosis tumors sensitizes sensory neurons more than nonpainful tumors, indicating secreted factors contribute to pain variability.

This study shows that intense pain reduces brain responses to auditory stimuli during HNCS, suggesting supraspinal mechanisms are involved in pain modulation.

The paper identifies the posterior parietal operculum as a region preferentially activated by heat pain over salient non-painful stimuli using fMRI and behavioral measures.

This study introduces a non-invasive muscle pain model using short-wave diathermy in humans, showing sustained hyperalgesia without significant skin sensitivity changes.

This study identifies GM-CSF's role in bone cancer pain by upregulating voltage-gated sodium channels via Jak2/Stat3 signaling in DRG neurons.

The paper analyzes human tibial nerve transcriptomes to identify sex-dimorphic gene expression related to pain, inflammation, and neuro-immunity.

This study shows that central sensitization increases pupil dilation and brain responses to pinprick stimuli, with pupil dilation being more sensitive than brain potentials.

The paper identifies sex-related gene expression differences in the dorsal root ganglion of male and female rats after nerve injury using RNA-seq.

The paper identifies a major QTL on chromosome 7 associated with acute thermal nociception in C57BL/6 mouse substrains.

This study shows that acute knee inflammation in mice sensitizes sensory neurons and reduces digging behavior, mediated by TRPV1 receptor upregulation.

This study shows that high frequency electrical stimulation increases N2 wave amplitude in brain potentials but not perception of intra-epidermal electrical stimuli in secondary hyperalgesia.

The paper shows that Nav1.7 loss of function analgesia requires both mu and delta opioid receptors, and enkephalin upregulation alone is insufficient for analgesia.

The paper identifies the transcriptomic profile of somatostatin-expressing interneurons in the spinal dorsal horn of mice, revealing novel genes and pathways relevant to mechanical pain.

This study identifies TrkB-expressing sensory neurons as key to mechanical allodynia and demonstrates their ablation as a treatment for neuropathic pain.

This study identifies sphingosine 1-phosphate and its receptor S1PR3 as critical regulators of mechanical pain by modulating mechanonociceptor excitability.