Developmental Biology and Gene Regulation

This study shows that actomyosin contractility in the Drosophila testis niche maintains its structure, which is essential for proper stem cell signaling and division orientation.

The paper examines muscle fiber distribution in twin-tail goldfish and finds similar patterns in related species, suggesting shared developmental mechanisms despite morphological differences.

The paper identifies functional motor neurons and cerebellum-like structures in the Ciona larval caudal CNS, suggesting homology with vertebrate spinal cord and cerebellum.

This study identifies OTX2 as a critical regulator of definitive endoderm specification and gut patterning through chromatin remodeling and signaling pathway regulation.

This study identifies gluconeogenic activity in the YSL-like tissue of cloudy catshark embryos, suggesting conserved yolk metabolism mechanisms between teleosts and elasmobranchs.

The paper studies BMP-Chordin signaling in brachiopods to reveal conserved dorsal-ventral patterning mechanisms across bilaterians.

The paper shows that local ecdysone synthesis in Drosophila wing blastemas sustains developmental delay and promotes regeneration by maintaining EcR activity.

This study shows that KAT3 mutations impair neural crest migration via EMT regulators snai1b and snai2 in Rubinstein Taybi Syndrome, using zebrafish models and human iPSC-derived cells.

The paper uses single-cell RNA-sequencing to map the differentiation trajectories of mammary stem cells and identifies spatial and molecular features of lineage commitment during mammary branching morphogenesis.

This study investigates the role of endoderm in shell field fate establishment in limpets by disrupting cell-cell contacts and shows that shell field differentiation in the 2q lineage occurs independently of interlineage interactions.

The paper examines how asymmetric stem cell division affects clonal dynamics in Drosophila germline stem cells, finding that it maintains genetic heterogeneity and prevents clonal expansion.

The paper uses pseudotime analysis of single-cell RNA-Seq data from mouse dorsal spinal interneurons to identify novel regulators and lineage relationships between interneuron populations.

The paper introduces a self-organizing model for mouse somitogenesis that generates phase waves through local cell communication, recapitulating in vivo and in vitro dynamics.

The paper investigates the developmental fate of zebrafish embryos lacking the reprogramming factors Nanog, Pou5f3, and Sox19b, finding that cells can acquire novel cell states or primordial germ cell-like states.

The paper investigates homologies in swallowtail butterfly wing patterns using phylogenetic analysis, CRISPR perturbation, and in situ experiments, revealing the role of Wnt signaling in shaping specific elements.

This study identifies mlt-11 as an NHR-23 target gene essential for C. elegans cuticle structure and function, showing its role in patterning cuticle layers and maintaining barrier integrity.

This paper introduces a 3D in vitro system to model human skeletal muscle development and identifies a pool of myogenic progenitors that can resist specification and expand in vitro.

The paper constructs a single-cell RNA sequencing atlas of spider embryos, revealing cell clusters, gene expression patterns, and developmental insights into arthropod embryogenesis.

This study investigates transcription factor dynamics during human enteroendocrine cell differentiation, finding that oscillations of ASCL1 and NEUROD1 enable accurate cell type diversification.

The paper uses single-cell RNA sequencing to analyze Drosophila embryonic salivary gland placodal cells, identifying genes involved in both induction and exclusion of expression during tube morphogenesis.

This paper shows Fasciclin 2 controls organ size and shape in Drosophila by acting as an expression-level switch that regulates EGFR activity through cell autonomous and non-cell autonomous mechanisms.

This study shows that cell cycle perturbation allows post-mitotic cells to maintain invasive behavior without exiting the cell cycle.

The paper examines pyloric sphincter formation in Xenopus laevis during metamorphosis, finding that it forms during metamorphic climax and involves gene expression changes similar to amniotes.

The paper shows that cell coupling compensates for altered Her6 dynamics in zebrafish neural progenitors, maintaining phenotypic robustness despite single-cell expression changes.

The paper identifies unique cell cycle variants in Drosophila accessory gland development, including post-eclosion endocycles and nuclear reprogramming.

The paper analyzes maternal gene expression patterns across 43 species to identify evolutionary signatures linked to reproductive modes.

This study investigates the temporal dynamics of apoptosis-induced proliferation in Drosophila pupal wings, revealing that this regenerative response declines after 35 hours APF due to ecdysone-responsive gene activity.

The paper shows that Notch dimerization is crucial for intestinal homeostasis, with HDAC2 activity modulating Notch function in intestinal stem cells.

The paper identifies a missense mutation in the edaradd gene causing developmental defects in ectodermal appendages in the mangrove killifish, confirming its role in fin and epithelial tissue development via the EDA signaling pathway.

The paper identifies genes regulated by MAB-5 in C. elegans Q neuroblasts, showing cwn-1/Wnt is downstream of MAB-5 in posterior migration.