Memory and Neural Mechanisms

This study investigates how statistical learning in spatial navigation shifts from hippocampal to medial prefrontal cortex representation over time using longitudinal iEEG data from an epilepsy patient.

This study identifies a neural circuit involving the ventral hippocampus and lateral septum that selectively mediates appetitive spatial memory for food or water locations.

The paper identifies a locus coeruleus-dorsal CA1 dopaminergic circuit that modulates memory linking without affecting memory formation.

This study examines how rat globus pallidus neurons encode movement and contextual information during a novel environment exposure task, revealing multidimensional responses and population-level encoding of locomotion speed and environmental novelty.

This study shows cholinergic modulation in the septo-hippocampal system changes rapidly with running speed and is logarithmically correlated to movement speed, independent of visual cues.

This study identifies a serotonin-modulated GABAergic pathway from the vPAG to the CeA that enhances fear learning through 5HT2C receptor activation.

This study shows that hippocampal place cells in rats modulate firing rates during replay events to distinguish contexts, revealing two complementary representations for memory.

This study investigates neural prediction error signals in aversive learning using fMRI in humans, finding asymmetric representation of threat omission PEs in the medial prefrontal cortex.

This study shows that cannabidiol prevents spontaneous fear recovery after delayed extinction and improves extinction resistance caused by immediate extinction in rats.

This study shows that anterior thalamic nuclei (ATN) lesions in rats impair non-spatial paired-associate memory, suggesting a role in attention to stimulus-stimulus associations rather than spatial processing.

This study identifies a functional role for entorhinal layer 6b subplate neurons in spatial learning and memory by showing their connectivity and impact on hippocampal activity.

This study investigates how ethanol exposure affects fear memory processing in mice and shows that optogenetic inhibition of hippocampal engrams reduces maladaptive contextual generalization.

The paper investigates how neural activity in afferent projections to the infralimbic cortex correlates with individual differences in fear extinction recall in rats.

This study decodes multiple navigational information types from DG neuron activity in mice, showing independent encoding of position, speed, motion direction, and future location.

The paper investigates beta bursting in the retrosplenial cortex of mice, finding it correlates with environmental novelty and is disrupted in a mouse model of Alzheimer's disease.

This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.

The paper shows that sleep co-reactivates relevant memories, enabling their assimilation and implicit learning.

This study shows that the dentate gyrus mediates stress-induced shifts in memory retrieval strategies in mice by regulating excitability through GAD65.

This paper introduces a model for continual learning in a recurrent neural network that combines Hebbian learning, synaptic decay, and a novel memory consolidation mechanism to avoid catastrophic forgetting.

The paper shows that constraints on neural network dynamics in a hippocampal model enable flexible offline memory replay of sensory sequences.

This study examines sex differences in fear memory, new neuron activation, and functional connectivity in the limbic system using rats.

The paper shows that in mouse hippocampus, CA1 pyramidal cells switch from being activated to inhibited by self-motion around postnatal day 7, linked to increased local GABAergic innervation.

This paper proposes a hierarchical generative model of the hippocampal formation that explains generative replay and continual learning through spatial navigation and memory organization.

The paper investigates the role of the anterior hippocampus in autobiographical memory construction across different memory ages, finding no temporal gradient during construction but strong anterior hippocampus activity regardless of memory remoteness.

The paper identifies a synaptic novelty signal in hippocampal circuits that drives a switch from generalization to discrimination during memory formation.

The paper shows that forgetting of extinction memory involves a dynamic shift in the connectivity of engram circuits between the mPFC, BLA, and vHPC.

This study identifies synaptic plasticity in motor engram neurons during motor learning, showing increased spine density and connectivity to striatal neurons.

This study investigates how reward motivation affects memory across development, finding age-related differences in neural mechanisms during encoding and post-encoding.

The paper investigates how thalamocortical circuits in the retrosplenial cortex process hippocampal sharp-wave ripples, finding reduced inhibition and subcortical input before SWR events.