Ion channel regulation and function

This study uses computational models to show that HCN channels have opposing effects on excitability of layer V pyramidal cells depending on dendritic location and neuromodulation.

This study shows that Kv2.1 channels form ER-PM junctions essential for ER Ca2+ uptake during neuronal activity, supporting synaptic transmission.

The paper uses personalized structural biology to analyze de novo KCNC2 variants in a DEE patient, revealing distinct functional effects of two nearby variants.

The paper shows that alternative splicing of β2-subunits stabilizes Cav2.3 Ca2+ channel activity in midbrain dopamine neurons, contributing to their vulnerability in Parkinson's disease.

This paper develops a multi-task learning model to predict the functional effects of voltage-gated potassium channel variants, achieving improved accuracy over standard methods.

This study presents cryo-EM structures of TWIK1 at different pH levels, revealing how protonation of an extracellular histidine triggers conformational changes that gate the K+ channel.

The paper evaluates three KCNMA1 variants in mice to correlate BK channel properties with neurobehavioral severity in PNKD3.

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

The paper identifies opposing transcription signals mediated by CaV1-encoded DCT peptides and shows they are regulated by C-terminus mediated inhibition.

This study shows that Kv3.3 subunits regulate presynaptic action potential waveform and neurotransmitter release at the calyx of Held synapse, affecting high-frequency transmission.

This paper develops a Bayesian filter with Kalman filtering to infer kinetic schemes for ion channels, showing improved accuracy and uncertainty quantification compared to classical methods.

This study identifies A-type FHFs as mediators of resurgent currents in TTX-resistant sodium channels, with FHF4A being critical for Nav1.8 and Nav1.9 channels, and shows its role in reducing neuronal excitability in nociceptive neurons.

This paper investigates the effects of the SCN2A p.K1422E variant in mice, showing mixed functional and behavioral impacts on neurons and neurodevelopmental phenotypes.

The paper investigates how long-term inactivation of NaV1.6 sodium channels contributes to adaptation in CA1 pyramidal neurons through a combined experimental and computational approach.

The paper shows that neurons can co-regulate multiple properties only if the number of adjustable ion channels exceeds the number of regulated properties, and that ion channel correlations arise when solution space dimensionality is low.

The paper shows that KCNQ channels help maintain stable presynaptic action potential waveforms during high-frequency firing, supporting reliable synaptic transmission in rat calyx of Held nerve terminals.

The paper models the temperature dependence of voltage-gated sodium channel kinetics using experimental data from rat neurons, showing differences in activation and inactivation temperature sensitivity and providing a temperature-spanning model for action potential generation.

This study identifies CBD's activation of Kv7 channels as a mechanism for its antiepileptic effects.

This study evaluates 79 KCNQ2 variants using automated patch clamp recording, revealing functional and pharmacological heterogeneity and genotype-dependent retigabine responses.

This study investigates the C-type inactivation mechanism in a Kv-like KcsA mutant, finding that the E71V mutation leads to a different structural conformation compared to wild-type KcsA.

The paper investigates the gating mechanisms of resurgent Na+ currents in mouse cerebellar Purkinje neurons using voltage-clamp recordings and a novel computational model.

The paper analyzes Ca2+ channel activity at lamprey reticulospinal synapses, showing a small number of channels trigger neurotransmitter release.

This study shows that CaV1.3 knockout mice have motor learning deficits and impaired gait adaptation but normal anxiety, depression, and social behaviors.

The paper identifies four neuronal types in spinal cord lamina VII, showing Kv3 channels are critical for fast firing in interneurons and synaptic inhibition of parasympathetic preganglionic neurons.

This study identifies Cav2.3 as a regulator of Kv4.2-mediated K+ current in hippocampal neurons, showing its role in synaptic input regulation and dendritic excitability.

This study shows that SGK1.1 activates the M-current in neurons and can counteract epilepsy-related mutations in Kv7.2 subunits.

The paper investigates how Kv1 channels influence spike patterning and temporal reliability in avian cochlear nucleus neurons, finding that they affect firing patterns and input sensitivity.

This study identifies resurgent Na+ currents in zebra finch projection neurons that enable ultrafast spiking for fine motor control.

This study identifies how persistent and hyperpolarization-activated inward currents shape motoneuron subtype recruitment during postnatal development in mice.