biodegradable polymer synthesis and properties

Robust cellular transformations of PET deconstruction products by import of glycol esters

This study demonstrates that E. coli can efficiently uptake and convert PET deconstruction products into upcycled reduction products with high yields.

Engineering Pseudomonas putida KT2440 for open-loop upcycling of mixed plastics

This study engineers Pseudomonas putida KT2440 to co-utilize five plastic monomers from mixed plastics, achieving complete substrate depletion and producing (R)-3-hydroxybutyrate.

Engineering xylose metabolism for diverse polyhydroxyalkanoates synthesis in Halomonas TD

This paper engineers Halomonas TD to produce diverse polyhydroxyalkanoates from xylose and glucose, achieving high yields of PHB and terpolymers through pathway modifications.

Material Composition and Implantation Site Affect in vivo Device Degradation Rate

This study investigates how material composition and implantation site affect in vivo degradation rates of tissue engineering devices using CT-visible radiopaque composites.

Spore-Based Biocomposite Thermoplastic Polyesters with Enhanced Toughness and Programmable Disintegration

This paper develops spore-based biocomposite thermoplastic polyesters with enhanced toughness and programmable disintegration through integration of heat-shock-tolerized Bacillus subtilis spores.

Burkholderia vietnamiensis Genes Involved in Extracellular Medium-Chain-Length Polyhydroxyalkanoate Degradation

This paper identifies genes in Burkholderia vietnamiensis responsible for extracellular degradation of medium-chain-length polyhydroxyalkanoates using transposon mutagenesis, Tn-seq, and CAST.

Biochemical Upcycling of PET via Glycolysis and Engineered Microbial Consortia

This paper presents a biochemical approach using glycolysis and engineered microbial consortia to upcycle post-consumer PET into PHAs, demonstrating efficient depolymerization and monomer conversion.

New-to-nature PHA synthase design using deep learning

This study uses a conditional variational autoencoder to design new-to-nature PHA synthases, which are validated for activity in yeast and show potential for expanding PHA material properties.

Design and Synthesis of Peptide-Polyester Conjugates for Cell-Mediated Scaffold Degradation

This paper designs and synthesizes peptide-polyester conjugates that degrade in response to cell-mediated protease activity, enhancing tissue regeneration.

Systematic development of degradable polyester biomaterials via ring-opening copolymerization of succinic anhydride and epoxides

This study develops degradable polyester biomaterials via ROCOP, showing that monomer selection significantly affects degradation behavior and material properties.

Insights into transcriptional expression and putative functions of multiple polyhydroxyalkanoate synthase paralogs in Haloferax mediterranei

This study investigates the transcriptional expression and potential functions of three phaC paralogs in Haloferax mediterranei under different physiological conditions, revealing their active expression and growth-phase-dependent regulation.

Cultivation in a Natural Microbial Community Enhances the Industrial Performance of a Genetically Engineered Cyanobacterium for Bioplastic Production

This paper shows that integrating a genetically engineered cyanobacterium into a natural microbial community improves its resilience and PHB production, making it suitable for industrial bioplastic production.

Improved nylon polymerization using amide diads

This paper demonstrates a method to produce higher-molecular-weight nylons using chemically-synthesized diads and biosynthetic amide synthetases, expanding the range of usable precursors.

A systems-level insight into PHB-driven metabolic adaptation orchestrated by the PHB-binding transcriptional regulator AniA (PhaR)

This study identifies PhaR as a key regulator of PHB-mediated metabolic adaptation in S. meliloti, revealing its impact on carbon metabolism and exopolysaccharide production.

Mesophilic compostability of polylactic acid and the associated microbiome as revealed by metagenomics

This study shows mesophilic composts can degrade polylactic acid (PLA) through a microbial community with hydro-lyase enzymes, overcoming the need for thermophilic temperatures.

Establishing Vibrio natriegens as a high-performance host for acetate-based poly-3-hydroxybutyrate production

This study enhances Vibrio natriegens' ability to produce poly-3-hydroxybutyrate from acetate through adaptive evolution and metabolic engineering, achieving high productivity and biomass accumulation.

Programming aliphatic polyester degradation by engineered bacterial spores

This paper demonstrates engineered bacterial spores displaying enzymes for sustainable aliphatic polyester degradation, showing repeated reuse and full activity recovery.

A novel recombinant PHB production platform in filamentous cyanobacteria avoiding nitrogen starvation while preserving cell viability

This paper develops a genetically engineered filamentous cyanobacterium that continuously produces PHB without nitrogen starvation, maintaining cell viability for sustainable industrial production.

An initial genome editing toolset for Caldimonas thermodepolymerans, the first model of thermophilic polyhydroxyalkanoates producer

This paper develops genome editing tools for Caldimonas thermodepolymerans, a thermophilic PHA producer, to enhance its biotechnological potential through genetic manipulation.

Scalable Fabrication of a Tough and Recyclable Spore-Bearing Biocomposite Thermoplastic Polyurethane

This paper develops a scalable method to create recyclable and tougher biocomposite TPUs by embedding spore-based living fillers, showing improved toughness and recyclability.

Polyhydroxybutyrate production in freshwater SAR11 (LD12)

This study investigates PHA production in SAR11 bacteria, finding that PHB synthesis is constitutive and may provide a fitness advantage.

Lack of functional polyester-biodegrading potential in marine versus terrestrial environments evidenced by an innovative airbrushing technique

This paper introduces an airbrushing technique to screen polyester biodegradation potential, revealing 1,000-fold higher activity in terrestrial than marine environments.

Unraveling the effects of polyhydroxyalkanoates accumulation in Pseudomonas extremaustralis growth and survival under different pH conditions

This study investigates how PHA accumulation affects P. extremaustralis growth and survival under varying pH conditions, finding that sclPHA primarily enhances survival against pH stress.

Eliminating Genes for a Two Component System Increases PHB Productivity in Cupriavidus basilensis 4G11 Under PHB Suppressing, Non-Stress Conditions

This study identifies two genes in a two-component system whose deletion increases PHB productivity in Cupriavidus basilensis under non-stress conditions.

AL-PHA beads: bioplastic-based protease biosensors for global health applications

The paper develops AL-PHA beads, bioplastic-based protease biosensors, and demonstrates their ability to detect specific proteases in various samples.

Streamlined production, purification, and comparison of recombinant extracellular polyhydroxybutyrate depolymerases

The paper describes a method for producing and comparing recombinant PhaZs from different bacterial strains, identifying optimal conditions for their activity.

Characterisation and modelling of a polyhydroxyalkanoate synthase from Aquitalea sp. USM4 reveals a mechanism for polymer elongation

The paper characterizes PhaC from Aquitalea sp. USM4 and models its mechanism, revealing a shared polymer elongation mechanism across PhaC classes and substrate specificity determinants.

Cell-free prototyping strategies for enhancing the sustainable production of polyhydroxyalkanoates bioplastics

This study develops cell-free systems to prototype and optimize polyhydroxyalkanoates biosynthesis, showing whey permeate enhances production and identifies enzymes for metabolite recycling.