Extracellular vesicles in disease

This study shows that milk-derived extracellular vesicles reduce NF-κB pathway and NLRP3 inflammasome activation in neonatal rats exposed to maternal high fat diet.

This paper develops ApoFilter, an aptamer-based method to remove lipoproteins from blood, enabling ultra-pure extracellular vesicle isolation with high efficiency and minimal EV loss.

This study uses morpho-mechanical analysis and machine learning to distinguish subpopulations of large extracellular vesicles based on their physical properties and mitochondrial content.

The paper designs peptides as alternatives to antibodies for detecting protein biomarkers on extracellular vesicles, showing comparable affinity to antibodies.

The paper shows that stress-induced changes in extracellular vesicles from mice can alter sperm and embryo transcriptomes, leading to metabolic issues in offspring.

This paper develops AdmirePred, a method to predict abundant miRNAs in exosomes using machine learning and hybrid approaches, achieving an AUC of 0.854.

This paper introduces a microfluidic platform for label-free single small extracellular vesicle counting in plasma without purification, using plasmonic nano-aperture imaging.

This paper develops an immunocapture method to isolate CD90+ stromal-derived EVs from arthritis synovial fluid and performs proteomic profiling to identify disease-relevant EV subpopulations and biomarkers.

This study develops hybrid extracellular vesicles (HEVs) for mRNA delivery, showing improved transfection efficiency and reduced cytotoxicity compared to conventional lipid nanoparticles.

This study shows tumor-derived extracellular vesicles containing serpins A1/A3 reprogram neutrophils to support tumor growth by extending their lifespan and suppressing CD8 T cells.

The paper develops a scalable workflow for transcriptomic profiling of urinary exRNA during pregnancy, identifying differentially expressed exRNAs associated with pregnancy-related changes.

The paper introduces a method to isolate and characterize extracellular vesicles and non-vesicular extracellular particles from mouse tissues for the first time.

This study shows that milk-derived extracellular vesicles enhance the heat shock response in female neonatal rats exposed to maternal high-fat diets, particularly in the prefrontal cortex.

The paper investigates how extracellular vesicles interact with B cells in nonhuman primates and humans, showing uptake via endocytosis and membrane fusion, and highlights potential strategies to modulate EV-B cell interactions.

This study shows that HuR in pancreatic cancer cells enhances angiogenesis by modulating extracellular vesicle signaling to endothelial cells, increasing their migratory and tube-forming abilities while reducing ICAM-1 expression.

This study identifies exosomal PCNA as a potential universal biomarker for early and pan-cancer detection through liquid biopsy, showing high specificity and sensitivity in serum samples.

The paper shows that human differentiated adipocytes can produce EVs similar to mature adipocytes, providing a reliable alternative for studying adipocyte-derived extracellular vesicles in obesity research.

This study examines how fungal extracellular vesicles mediate communication between fungal species and modulate immune responses, revealing their role in virulence and biofilm formation.

The paper introduces a SERS-based method to detect hepatotoxicity by analyzing extracellular vesicle content, showing strong correlations with conventional toxicity biomarkers.

This paper develops a hyaluronic acid hydrogel system for sustained delivery of extracellular vesicles, demonstrating scalable production and controlled release in vitro.

This study investigates whether MSC-EVs elicit an immune response in tumor-bearing mice and finds no significant immune activation, supporting their immune privilege and therapeutic potential.

This study shows that EVs from angio-miRNA-modified MSCs enhance angiogenesis in ischemic models, with combined EVs showing greater efficacy.

The paper identifies 12 microRNAs with differential expression in L1CAM-associated extracellular vesicles linked to oral contraceptive use and links them to the Gonadotropin-releasing hormone receptor pathway.

This study shows that matrix stiffness modulates EV release and cargo from cancer spheroids, with stiff matrices promoting tumorigenic and metastatic profiles in EVs.

The paper identifies distinct proteomic signatures in brain-derived extracellular vesicles from 3R and 4R tauopathies, linking them to disease-specific cellular and molecular changes.

This study uses BEST and MBA to track extracellular vesicle cargo in gastric cancer, showing saliva as the best biofluid for diagnosis.

This study shows that activating Piezo1 ion channels via mechanical shear stress increases extracellular vesicle production from adipose-derived stromal cells in bioreactors.

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.