Cardiovascular Health and Disease Prevention

Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults

This study examines the relationship between cerebral arterial elasticity and cardiovascular health in older adults, finding that higher cardiovascular risk burden is associated with lower cerebral arterial elasticity.

Integrated Multiomics Links Metabolic and Inflammatory Remodeling to Arterial Stiffness After the 4,486-km Trans Europe Footrace

This study links metabolic and inflammatory changes to arterial stiffness in ultra-endurance runners using multi-omics analysis of plasma samples.

Smooth muscle cell estrogen receptor alpha promotes arterial stiffness in the absence of estradiol

This study shows that smooth muscle cell estrogen receptor alpha promotes arterial stiffness in both female and male mice when estradiol levels are low, through sex-specific mechanisms.

Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability

The paper investigates how regional cerebral arterial elasticity relates to grey matter volume decline with age, finding partial mediation in the left prefrontal cortex and sex-specific effects.

Impact of cell type specific variations and age in aortic distensibility

The paper investigates how age and cell type-specific gene expression affect aortic distensibility using bulk gene expression data and GWAS findings.

The Impact of Age and Sex on Cerebral and Large Artery Stiffness and the Response to Pulse Pressure

This study examines how age and sex affect cerebral and large artery stiffness and their response to pulse pressure in mice, finding that young females have more compliant arteries susceptible to endothelial dysfunction.

Age-Related Decline in NCKX4-Mediated Calcium Clearance Accelerates Aortic Remodeling and Drives Early Vascular Aging

This study identifies NCKX4 as a key regulator of vascular aging, showing its decline accelerates aortic remodeling and calcification in aged mice, particularly in females.

A Frequency-Domain Framework for Cardiovascular Power Distribution

This paper introduces a frequency-domain framework for cardiovascular power distribution, modeling the heart as a multi-frequency power source and organs as frequency-tuned loads, with simulation results supporting its physiological and clinical relevance.

Biomechanical stress, inflammatory change and atheromatous plaque detachment: the role of pulse pressure, arterial wall stiffness and vessel bending. An in-vitro experimental study with some clinical implications

This study investigates the in vitro forces causing atheromatous plaque detachment, finding strong correlations between critical detachment force and pulse pressure, wall stiffness, and vessel bending.

Sex Differences in Middle Cerebral Artery Reactivity and Hemodynamics Independent from Changes in Systemic Arterial Stiffness in Adult Sprague-Dawley Rats

Deletion of RSK2 kinase alleviates age-dependent hypertension

This study shows that deleting RSK2 kinase in aged mice reduces hypertension by improving vascular relaxation and reducing vessel stiffness.

Pharmacological Activation of NO-Sensitive Guanylyl Cyclase Ameliorates Obesity-Induced Arterial Stiffness

This study shows that activating NO-sensitive guanylyl cyclase with cinaciguat reduces obesity-induced arterial stiffness by decreasing VSMC cytoskeletal actin polymerization.

Genetic and Etiological Insights from Automated Lumen Diameter Measurements in Carotid Ultrasounds of the UK Biobank

The paper develops a deep learning model to measure carotid lumen diameter from ultrasounds and performs GWAS, finding cLD has higher heritability and stronger associations with cardiovascular risk factors than cIMT.

The MAASWERP study: An international, comparative case study on measuring biomechanics of the aged murine aorta

The study compares two ex vivo setups for measuring aortic stiffness in aged mice, finding method-specific differences in stiffness parameters and smooth muscle cell effects.

Neurovascular Mechanisms of Cognitive Aging: Sex-Related Differences in the Average Progression of Arteriosclerosis, White Matter Atrophy, and Cognitive Decline

The paper investigates sex-related differences in the progression of arteriosclerosis, white matter atrophy, and cognitive decline using neuroimaging and behavioral data.

Regulatory Roles of Long Non-Coding RNAs in Arterial Stiffness and Hypertension: Insights from Two African American Studies

This study identifies lncRNAs and mRNAs associated with arterial stiffness and hypertension in African American populations using transcriptome data from two cohorts.

Cross-organ Analysis Reveals Associations between Vascular Properties of the Retina, the Carotid and Aortic Artery, and the Brain

The paper examines cross-organ vascular correlations using UK Biobank data, finding shared genetic influences and vascular morphology links between retina, carotid, aorta, and brain.

Sex moderates the relationship between aortic stiffness, cognition and cerebrovascular reactivity in healthy older adults

This study examines how sex and hematocrit influence the relationship between aortic stiffness, cerebrovascular reactivity, and cognitive function in older adults.

Carotid intima-media thickness in UK Biobank: Identification of novel genome-wide loci, sex-specific effects and genetic correlations with obesity and glucometabolic traits.

Sex differences in interrelationships between arterial stiffness, carotid intima-media thickness, white matter hyperintensities, depression and cognition: A UK Biobank study

Genetic Association of Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease

This study investigates whether genetic predisposition to higher arterial stiffness index (ASI) is associated with blood pressure and coronary artery disease risk, finding a link with blood pressure but not CAD.